PDF(Pubmed)
Abstract：
Campylobacter jejuni is a very common cause of gastroenteritis, and is frequently transmitted to humans through contaminated food products or water. Importantly, C. jejuni infections have a range of short- and long-term sequelae such as irritable bowel syndrome and Guillain Barre syndrome. C. jejuni triggers disease by employing a range of molecular strategies which enable it to colonise the gut, invade the epithelium, persist intracellularly and avoid detection by the host immune response. The objective of this review is to explore and summarise recent advances in the understanding of the C. jejuni molecular factors involved in colonisation, invasion of cells, collective quorum sensing-mediated behaviours and persistence. Understanding the mechanisms that underpin the pathogenicity of C. jejuni will enable future development of effective preventative approaches and vaccines against this pathogen.
摘要：
空肠弯曲菌是引起肠胃炎的一个非常常见的原因,并经常通过受污染的食品或水传播给人类。重要的是,空肠杆菌感染有一系列短期和长期后遗症，如肠易激综合征和格林巴利综合征。空肠弯曲杆菌通过采用一系列分子策略来引发疾病，使其能够在肠道定殖，侵入上皮，持续在细胞内，避免被宿主免疫反应检测。这篇综述的目的是探索和总结对参与定殖的空肠弯曲杆菌分子因素的理解的最新进展。入侵细胞，集体群体感应介导的行为和持久性。了解支持空肠弯曲杆菌致病性的机制将使未来能够开发针对该病原体的有效预防方法和疫苗。
