PDF(Pubmed)
Abstract：
OBJECTIVE: This split-mouth randomized study aimed to assess efficacy of leucocyte-platelet-rich fibrin (L-PRF) versus connective tissue graft (CTG) in achieving root coverage (RC) for multiple adjacent gingival recessions (MAGRs) throughout 12-month period.
METHODS: The study enrolled 59 teeth from 12 patients with Miller Class I MAGRs ≥ 2 mm on bilateral or contralateral sides. Patients were randomly assigned to receive coronally advanced flap (CAF) with either CTG (control) or L-PRF (test) treatment. Various parameters, including plaque and gingival index, clinical attachment level, recession depth, probing depth, recession width (RW), papilla width (PW), keratinized tissue width (KTW), gingival thickness (GT), percentage of RC, complete root coverage (CRC), and location of the relative gingival margin concerning the cemento-enamel junctions (GMCEJ) after CAF, were recorded at baseline, 3-, 6-, and 12-months post-surgery. On June 29, 2021 the study was registred to ClinicalTrials.gov (NCT04942821).
RESULTS: Except KTW and GT gain, all clinical parameters, RC, and CRC were similar between the groups at all follow-up periods (p > 0.05). The higher GT and KTW gains were detected in the control group compared to test group at 12 months (p < 0.05). Both RC and CRC were positively associated with initial PW and GMCEJ, but negatively with initial RW (p < 0.05).
CONCLUSIONS: The current study concludes that L-PRF were equally effective as CTG in treating MAGRs in terms of RC and CRC. Additionally, RC and CRC outcomes appeared to be influenced by GMCEJ, PW, and RW.
CONCLUSIONS: L-PRF could represent a feasible substitute for CTG in treating MAGRs.
METHODS: The study enrolled 59 teeth from 12 patients with Miller Class I MAGRs ≥ 2 mm on bilateral or contralateral sides. Patients were randomly assigned to receive coronally advanced flap (CAF) with either CTG (control) or L-PRF (test) treatment. Various parameters, including plaque and gingival index, clinical attachment level, recession depth, probing depth, recession width (RW), papilla width (PW), keratinized tissue width (KTW), gingival thickness (GT), percentage of RC, complete root coverage (CRC), and location of the relative gingival margin concerning the cemento-enamel junctions (GMCEJ) after CAF, were recorded at baseline, 3-, 6-, and 12-months post-surgery. On June 29, 2021 the study was registred to ClinicalTrials.gov (NCT04942821).
RESULTS: Except KTW and GT gain, all clinical parameters, RC, and CRC were similar between the groups at all follow-up periods (p > 0.05). The higher GT and KTW gains were detected in the control group compared to test group at 12 months (p < 0.05). Both RC and CRC were positively associated with initial PW and GMCEJ, but negatively with initial RW (p < 0.05).
CONCLUSIONS: The current study concludes that L-PRF were equally effective as CTG in treating MAGRs in terms of RC and CRC. Additionally, RC and CRC outcomes appeared to be influenced by GMCEJ, PW, and RW.
CONCLUSIONS: L-PRF could represent a feasible substitute for CTG in treating MAGRs.
摘要：
目的：这项分口随机研究旨在评估富含白细胞-血小板纤维蛋白（L-PRF）与结缔组织移植物（CTG）在12个月期间多个邻近牙龈凹陷（MAGR）中实现根覆盖率（RC）的疗效。
方法：该研究纳入了12例患者的59颗牙齿，这些患者的MillerClassIMAGR在双侧或对侧≥2mm。患者被随机分配接受冠状推进皮瓣（CAF）与CTG（对照）或L-PRF（测试）治疗。各种参数，包括菌斑和牙龈指数，临床依恋水平，衰退深度，探测深度,衰退宽度(RW)，乳头宽度（PW），角化组织宽度（KTW），牙龈厚度（GT），RC的百分比，完全根覆盖(CRC)，以及CAF后有关牙骨质-牙釉质连接（GMCEJ）的相对牙龈边缘的位置，在基线时记录，3-,6-，术后12个月.2021年6月29日，该研究已注册到ClinicalTrials.gov（NCT04942821）。
结果：除KTW和GT增益外，所有临床参数,RC,在所有随访期间，两组之间的CRC相似（p>0.05）。在12个月时,与试验组相比,在对照组中检测到更高的GT和KTW增益(p<0.05)。RC和CRC均与初始PW和GMCEJ呈正相关，但与初始RW呈负相关(p<0.05)。
结论：目前的研究得出结论，L-PRF在RC和CRC方面与CTG治疗MAGR同样有效。此外,RC和CRC结果似乎受到GMCEJ的影响，PW,和RW。
结论：L-PRF可以替代CTG治疗MAGR。
方法：该研究纳入了12例患者的59颗牙齿，这些患者的MillerClassIMAGR在双侧或对侧≥2mm。患者被随机分配接受冠状推进皮瓣（CAF）与CTG（对照）或L-PRF（测试）治疗。各种参数，包括菌斑和牙龈指数，临床依恋水平，衰退深度，探测深度,衰退宽度(RW)，乳头宽度（PW），角化组织宽度（KTW），牙龈厚度（GT），RC的百分比，完全根覆盖(CRC)，以及CAF后有关牙骨质-牙釉质连接（GMCEJ）的相对牙龈边缘的位置，在基线时记录，3-,6-，术后12个月.2021年6月29日，该研究已注册到ClinicalTrials.gov（NCT04942821）。
结果：除KTW和GT增益外，所有临床参数,RC,在所有随访期间，两组之间的CRC相似（p>0.05）。在12个月时,与试验组相比,在对照组中检测到更高的GT和KTW增益(p<0.05)。RC和CRC均与初始PW和GMCEJ呈正相关，但与初始RW呈负相关(p<0.05)。
结论：目前的研究得出结论，L-PRF在RC和CRC方面与CTG治疗MAGR同样有效。此外,RC和CRC结果似乎受到GMCEJ的影响，PW,和RW。
结论：L-PRF可以替代CTG治疗MAGR。
