Abstract：
Two new sesterterpenoids, sesterchaetins A and B (1 and 2), and two new diepoxide polyketides, chaetoketoics A and B (3 and 4), were characterized from the culture extract of Chaetomium globosum SD-347, a fungal strain derived from deep sea-sediment. Their structures and absolute configurations were unambiguously determined by detailed NMR, mass spectra, and X-ray crystallographic analysis. Compounds 1 and 2 contained a distinctive 5/8/6/5 tetracyclic carbon-ring-system, which represented a rarely occurring natural product framework. The new isolates 1-4 exhibited selective antimicrobial activities against human and aquatic pathogenic bacteria and plant-pathogenic fungi.
摘要：
两种新的类脂萜类化合物，SesterchaetinsA和B（1和2），和两种新的二环氧化物聚酮化合物，ChaetoketoicsA和B（3和4），从来自深海沉积物的真菌菌株球形毛霉SD-347的培养提取物中表征。通过详细的NMR明确确定了它们的结构和绝对构型，质谱,和X射线晶体学分析。化合物1和2含有独特的5/8/6/5四环碳环系统，这代表了一种罕见的天然产品框架。新分离株1-4对人类和水生病原菌以及植物病原真菌具有选择性抗菌活性。
