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Abstract：
Laryngopharyngeal reflux disease (LPRD) is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the esophagus. LPRD commonly presents with sym-ptoms such as hoarseness, cough, sore throat, a feeling of throat obstruction, excessive throat mucus. This complex condition is thought to involve both reflux and reflex mechanisms, but a clear understanding of its molecular mechanisms is still lacking. Currently, there is no standardized diagnosis or treatment protocol. Therapeutic strategies for LPRD mainly include lifestyle modifications, proton pump inhibitors and endoscopic surgery. This paper seeks to provide a comprehensive overview of the existing literature regarding the mechanisms, patho-physiology and treatment of LPRD. We also provide an in-depth exploration of the association between LPRD and gastroesophageal reflux disease.
摘要：
喉咽反流病（LPRD）是由胃内容物反流到食道以外引起的喉咽和上消化道粘膜的炎症。LPRD通常表现为症状，如声音嘶哑，咳嗽,喉咙痛,喉咙阻塞的感觉，喉咙粘液过多。这种复杂的情况被认为涉及反流和反射机制，但是仍然缺乏对其分子机制的清晰了解。目前,没有标准化的诊断或治疗方案.LPRD的治疗策略主要包括改变生活方式，质子泵抑制剂和内窥镜手术。本文旨在提供有关机制的现有文献的全面概述，LPRD的病理生理学和治疗。我们还对LPRD与胃食管反流病之间的关系进行了深入的探索。
