PDF(Pubmed)
Abstract：
Metastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfunction of splicing factors and abnormal expression of splicing variants are associated with the occurrence, progression, aggressiveness, and drug resistance of cancers caused by the selective splicing of specific genes. This review is the first to provide a detailed summary of the normal splicing process and alterations that occur during metastatic liver cancer. It will cover the role of alternative splicing in the mechanisms of metastatic liver cancer by examining splicing factor changes, abnormal splicing, and the contribution of hypoxia to these changes during metastasis.
摘要：
转移仍然是成功管理恶性疾病的主要挑战。肝脏是转移性疾病的主要部位，也是胃肠道恶性肿瘤如结肠等死亡的主要原因。胃,和胰腺癌，以及黑色素瘤，乳腺癌,和肉瘤.作为影响转移性肝癌发生发展的重要因素,选择性剪接驱动RNA转录本和蛋白质亚型的多样性，这可能为扩大目标空间提供潜力。特别是,剪接因子的功能障碍和剪接变异体的异常表达与剪接因子的发生有关,programming,侵略性,以及特定基因的选择性剪接引起的癌症耐药性。这篇综述是第一个详细概述正常剪接过程和转移性肝癌发生的改变。它将通过检查剪接因子的变化来涵盖选择性剪接在转移性肝癌机制中的作用，异常拼接，以及转移过程中缺氧对这些变化的贡献。
