PDF(Pubmed)
Abstract：
The trend of aging of the global population is becoming more and more significant, and the incidence of age-related diseases continues to rise.This phenomenon makes the problem of aging gradually attracted wide attention of the society, and gradually developed into an independent research field.As a vital defense mechanism of the human body, the immune system changes significantly during the aging process.Age-induced changes in the body\'s immune system are considered harmful and are commonly referred to as immune aging, which may represent the beginning of systemic aging.Immune cells, especially T cells, are the biggest influencers and participants in age-related deterioration of immune function, making older people more susceptible to different age-related diseases.More and more evidence shows that T cells play an important role in the change of human tissue structure after aging, which fundamentally affects the health and survival of the elderly.In this review, we discuss the general characteristics of age-related T cell immune alterations and the possible effects of aging T cells in various tissue structures in the human body.
摘要：
全球人口老龄化趋势日益显著,与年龄有关的疾病的发病率继续上升。这一现象使得老龄化问题逐渐引起了社会的广泛关注,并逐渐发展成为一个独立的研究领域。作为人体的重要防御机制，免疫系统在衰老过程中会发生显著变化。年龄引起的身体免疫系统的变化被认为是有害的，通常被称为免疫老化，这可能代表了系统衰老的开始。免疫细胞,尤其是T细胞,是与年龄相关的免疫功能恶化的最大影响者和参与者，使老年人更容易受到不同年龄相关疾病的影响。越来越多的证据表明，T细胞在衰老后人体组织结构的改变中起着重要作用，从根本上影响老年人的健康和生存。在这次审查中,我们讨论了与年龄相关的T细胞免疫改变的一般特征以及衰老T细胞在人体各种组织结构中的可能影响。
