PDF(Pubmed)
Abstract：
BACKGROUND: The current study examined the contributions of comprehensive neuropsychological assessment and volumetric assessment of selected mesial temporal subregions on structural magnetic resonance imaging (MRI) to identify patients with amnestic mild cognitive impairment (aMCI) and mild probable Alzheimer\'s disease (AD) dementia in a memory clinic cohort.
METHODS: Comprehensive neuropsychological assessment and automated entorhinal, transentorhinal, and hippocampal volume measurements were conducted in 40 healthy controls, 38 patients with subjective memory symptoms, 16 patients with aMCI, 16 patients with mild probable AD dementia. Multinomial logistic regression was used to compare the neuropsychological and MRI measures.
RESULTS: Combining the neuropsychological and MRI measures improved group membership prediction over the MRI measures alone but did not improve group membership prediction over the neuropsychological measures alone.
CONCLUSIONS: Comprehensive neuropsychological assessment was an important tool to evaluate cognitive impairment. The mesial temporal volumetric MRI measures contributed no diagnostic value over and above the determinations made through neuropsychological assessment.
METHODS: Comprehensive neuropsychological assessment and automated entorhinal, transentorhinal, and hippocampal volume measurements were conducted in 40 healthy controls, 38 patients with subjective memory symptoms, 16 patients with aMCI, 16 patients with mild probable AD dementia. Multinomial logistic regression was used to compare the neuropsychological and MRI measures.
RESULTS: Combining the neuropsychological and MRI measures improved group membership prediction over the MRI measures alone but did not improve group membership prediction over the neuropsychological measures alone.
CONCLUSIONS: Comprehensive neuropsychological assessment was an important tool to evaluate cognitive impairment. The mesial temporal volumetric MRI measures contributed no diagnostic value over and above the determinations made through neuropsychological assessment.
摘要：
背景：当前的研究检查了综合神经心理学评估和选定的内侧颞区的体积评估对结构磁共振成像（MRI）的贡献，以识别记忆临床队列中遗忘型轻度认知障碍（aMCI）和轻度可能的阿尔茨海默病（AD）痴呆的患者。
方法：全面的神经心理学评估和自动内嗅，跨昆虫,在40名健康对照中进行了海马体积测量，38例患者有主观记忆症状，16例aMCI患者，16例轻度可能的AD痴呆患者。多项逻辑回归用于比较神经心理学和MRI测量。
结果：神经心理学和MRI措施的结合改善了单独的MRI措施的组成员预测，但没有改善单独的神经心理学措施的组成员预测。
结论：综合神经心理学评估是评估认知障碍的重要工具。超过通过神经心理学评估做出的决定，内侧颞叶容积MRI测量没有贡献诊断价值。
方法：全面的神经心理学评估和自动内嗅，跨昆虫,在40名健康对照中进行了海马体积测量，38例患者有主观记忆症状，16例aMCI患者，16例轻度可能的AD痴呆患者。多项逻辑回归用于比较神经心理学和MRI测量。
结果：神经心理学和MRI措施的结合改善了单独的MRI措施的组成员预测，但没有改善单独的神经心理学措施的组成员预测。
结论：综合神经心理学评估是评估认知障碍的重要工具。超过通过神经心理学评估做出的决定，内侧颞叶容积MRI测量没有贡献诊断价值。
