Abstract：
Trousseau syndrome is characterized by cancer-associated systemic thrombosis. We describe the first case of a successfully treated gallbladder adenocarcinoma accompanied by Trousseau syndrome. A 66-year-old woman presented with right hemiplegia. Magnetic resonance imaging identified multiple cerebral infarctions. Her serum carbohydrate antigen 19-9 and D-dimer levels were markedly elevated, and a gallbladder tumor was detected via abdominal computed tomography. Venous ultrasonography of the lower limbs revealed a deep venous thrombus in the right peroneal vein. These findings suggested that the brain infarctions were likely caused by Trousseau syndrome associated with her gallbladder cancer. Radical resection of the gallbladder tumor was performed. The resected gallbladder was filled with mucus and was pathologically diagnosed as an adenocarcinoma. Her postoperative course was uneventful, and she received a one-year course of adjuvant therapy with oral S-1. No cancer recurrence or thrombosis was noted 26 months postoperatively. Despite concurrent Trousseau syndrome, a radical cure of the primary tumor and thrombosis could be achieved with the appropriate treatment.
摘要：
Trousseau综合征的特征是癌症相关的全身性血栓形成。我们描述了第一例成功治疗的伴有Trousseau综合征的胆囊腺癌。一名66岁的妇女出现右偏瘫。磁共振成像发现多发性脑梗塞。她的血清碳水化合物抗原19-9和D-二聚体水平显着升高，通过腹部计算机断层扫描检测到胆囊肿瘤。下肢静脉超声检查显示右腓骨静脉有深静脉血栓。这些发现表明，脑梗塞可能是由与胆囊癌相关的Trousseau综合征引起的。对胆囊肿瘤进行了根治性切除术。切除的胆囊充满粘液，经病理诊断为腺癌。她的术后进展顺利，她接受了为期一年的口服S-1辅助治疗。术后26个月无癌症复发或血栓形成。尽管同时发生Trousseau综合征,通过适当的治疗可以实现原发性肿瘤和血栓形成的根治。
