METHODS: Retrospective, observational, and analytical study.
METHODS: COVID-19 ICU of a tertiary hospital.
METHODS: Adults over 18 years old, with a confirmed diagnosis of SARS-CoV-2 disease requiring PPM.
METHODS: Multivariable analysis of 90-day survival.
METHODS: Duration of the first PPM, number of PPM sessions, 90-day mortality.
RESULTS: 271 patients undergoing PPM were analyzed: first tertile (n = 111), second tertile (n = 95) and third tertile (n = 65). The results indicated that the median duration of PDP was 14 h (95% CI: 10-16 h) in the first tertile, 19 h (95% CI: 18-20 h) in the second tertile and 22 h (95% CI: 21-24 h) in the third tertile. Comparison of survival curves using the Logrank test did not reach statistical significance (p = 0.11). Cox Regression analysis showed an association between the number of pronation sessions (patients receiving between 2 and 5 sessions (HR = 2.19; 95% CI: 1.07-4.49); and those receiving more than 5 sessions (HR = 6.05; 95% CI: 2.78-13.16) and 90-day mortality.
CONCLUSIONS: while the duration of PDP does not appear to significantly influence 90-day mortality, the number of pronation sessions is identified as a significant factor associated with an increased risk of mortality.
方法:回顾性,观察,和分析研究。
方法:某三级医院COVID-19ICU。
方法:18岁以上的成年人,确诊为需要PPM的SARS-CoV-2病。
方法:90天生存率的多变量分析。
方法:第一个PPM的持续时间,PPM会话的数量,90天死亡率。
结果:分析了271例接受PPM的患者:第一三位数(n=111),第二三元(n=95)和第三三元(n=65)。结果表明,PDP的中位持续时间为14h(95%CI:10-16h),第二个三分位数为19小时(95%CI:18-20小时),第三个三分位数为22小时(95%CI:21-24小时)。使用Logrank检验的存活曲线的比较未达到统计学显著性(p=0.11)。Cox回归分析显示内旋次数(接受2至5次治疗的患者(HR=2.19;95%CI:1.07-4.49);接受5次以上治疗的患者(HR=6.05;95%CI:2.78-13.16)与90天死亡率之间存在关联。
结论:虽然PDP的持续时间似乎对90天死亡率没有显著影响,内旋次数被认为是与死亡风险增加相关的一个重要因素.