Abstract：
OBJECTIVE: To investigate the association between the duration of the first prone positioning maneuver (PPM) and 90-day mortality in patients with C-ARDS.
METHODS: Retrospective, observational, and analytical study.
METHODS: COVID-19 ICU of a tertiary hospital.
METHODS: Adults over 18 years old, with a confirmed diagnosis of SARS-CoV-2 disease requiring PPM.
METHODS: Multivariable analysis of 90-day survival.
METHODS: Duration of the first PPM, number of PPM sessions, 90-day mortality.
RESULTS: 271 patients undergoing PPM were analyzed: first tertile (n = 111), second tertile (n = 95) and third tertile (n = 65). The results indicated that the median duration of PDP was 14 h (95% CI: 10-16 h) in the first tertile, 19 h (95% CI: 18-20 h) in the second tertile and 22 h (95% CI: 21-24 h) in the third tertile. Comparison of survival curves using the Logrank test did not reach statistical significance (p = 0.11). Cox Regression analysis showed an association between the number of pronation sessions (patients receiving between 2 and 5 sessions (HR = 2.19; 95% CI: 1.07-4.49); and those receiving more than 5 sessions (HR = 6.05; 95% CI: 2.78-13.16) and 90-day mortality.
CONCLUSIONS: while the duration of PDP does not appear to significantly influence 90-day mortality, the number of pronation sessions is identified as a significant factor associated with an increased risk of mortality.
METHODS: Retrospective, observational, and analytical study.
METHODS: COVID-19 ICU of a tertiary hospital.
METHODS: Adults over 18 years old, with a confirmed diagnosis of SARS-CoV-2 disease requiring PPM.
METHODS: Multivariable analysis of 90-day survival.
METHODS: Duration of the first PPM, number of PPM sessions, 90-day mortality.
RESULTS: 271 patients undergoing PPM were analyzed: first tertile (n = 111), second tertile (n = 95) and third tertile (n = 65). The results indicated that the median duration of PDP was 14 h (95% CI: 10-16 h) in the first tertile, 19 h (95% CI: 18-20 h) in the second tertile and 22 h (95% CI: 21-24 h) in the third tertile. Comparison of survival curves using the Logrank test did not reach statistical significance (p = 0.11). Cox Regression analysis showed an association between the number of pronation sessions (patients receiving between 2 and 5 sessions (HR = 2.19; 95% CI: 1.07-4.49); and those receiving more than 5 sessions (HR = 6.05; 95% CI: 2.78-13.16) and 90-day mortality.
CONCLUSIONS: while the duration of PDP does not appear to significantly influence 90-day mortality, the number of pronation sessions is identified as a significant factor associated with an increased risk of mortality.
摘要：
目的：研究C-ARDS患者首次俯卧位动作（PPM）持续时间与90天死亡率之间的关系。
方法：回顾性，观察,和分析研究。
方法：某三级医院COVID-19ICU。
方法：18岁以上的成年人，确诊为需要PPM的SARS-CoV-2病。
方法：90天生存率的多变量分析。
方法：第一个PPM的持续时间，PPM会话的数量，90天死亡率。
结果：分析了271例接受PPM的患者：第一三位数（n=111），第二三元(n=95)和第三三元(n=65)。结果表明，PDP的中位持续时间为14h(95%CI:10-16h)，第二个三分位数为19小时（95％CI：18-20小时），第三个三分位数为22小时（95％CI：21-24小时）。使用Logrank检验的存活曲线的比较未达到统计学显著性(p=0.11)。Cox回归分析显示内旋次数（接受2至5次治疗的患者（HR=2.19；95％CI：1.07-4.49）；接受5次以上治疗的患者（HR=6.05；95％CI：2.78-13.16）与90天死亡率之间存在关联。
结论：虽然PDP的持续时间似乎对90天死亡率没有显著影响，内旋次数被认为是与死亡风险增加相关的一个重要因素.
方法：回顾性，观察,和分析研究。
方法：某三级医院COVID-19ICU。
方法：18岁以上的成年人，确诊为需要PPM的SARS-CoV-2病。
方法：90天生存率的多变量分析。
方法：第一个PPM的持续时间，PPM会话的数量，90天死亡率。
结果：分析了271例接受PPM的患者：第一三位数（n=111），第二三元(n=95)和第三三元(n=65)。结果表明，PDP的中位持续时间为14h(95%CI:10-16h)，第二个三分位数为19小时（95％CI：18-20小时），第三个三分位数为22小时（95％CI：21-24小时）。使用Logrank检验的存活曲线的比较未达到统计学显著性(p=0.11)。Cox回归分析显示内旋次数（接受2至5次治疗的患者（HR=2.19；95％CI：1.07-4.49）；接受5次以上治疗的患者（HR=6.05；95％CI：2.78-13.16）与90天死亡率之间存在关联。
结论：虽然PDP的持续时间似乎对90天死亡率没有显著影响，内旋次数被认为是与死亡风险增加相关的一个重要因素.
