METHODS: In this retrospective cohort study conducted with data from the TriNetX database, 53,716 patients with HS were matched to an equivalent number of non-HS controls using propensity score matching. The study covered the period from January 1st, 2005, to December 31st, 2017. Hazard ratios and their respective 95% confidence intervals (CIs), were computed to evaluate the occurrences of keratitis and keratopathy over a 5-year duration in patients with HS, compared to non-HS controls.
RESULTS: HS was associated with a 1.52 times higher risk of keratitis over a 5-year period (95%CI=1.24-1.86) and a 1.47 times higher risk of keratopathy (95%CI=1.18-1.84). These risks remained consistent in sensitivity analyses. The elevated risk of keratitis was observed across both sexes. However, the risk of keratopathy was significantly higher in women with HS (HR=1.61, 95%CI=1.24-2.10) and individuals aged 18-64 years (HR=1.32, 95%CI=1.04-1.68).
CONCLUSIONS: HS was linked to an elevated risk of both keratitis and keratopathy over a 5-year period. Ophthalmologic manifestations are recommended to be considered in HS standard care.
方法:在这项使用TriNetX数据库数据进行的回顾性队列研究中,使用倾向评分匹配将53,716例HS患者与同等数量的非HS对照进行匹配。这项研究涵盖了从1月1日开始的时期,2005年12月31日,2017.危险比及其各自的95%置信区间(CI),计算以评估HS患者在5年内的角膜炎和角膜病变的发生情况,与非HS对照相比。
结果:HS与5年期间的角膜炎风险高1.52倍(95CI=1.24-1.86)和角膜病变风险高1.47倍(95CI=1.18-1.84)相关。这些风险在敏感性分析中保持一致。在两种性别中都观察到角膜炎的风险升高。然而,HS患者(HR=1.61,95CI=1.24~2.10)和18~64岁患者(HR=1.32,95CI=1.04~1.68)的角膜病变风险显著增高.
结论:HS与5年期间角膜炎和角膜病变的风险升高有关。建议在HS标准护理中考虑眼科表现。