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Abstract：
OBJECTIVE: Hidradenitis suppurativa (HS) is linked to immune dysregulation and systemic inflammation. While previous studies indicate a higher prevalence of ocular manifestations in HS, the specific risk of keratopathy and keratitis remains unclear. The primary aim of this study was to assess the risk of keratitis and keratopathy in individuals with HS.
METHODS: In this retrospective cohort study conducted with data from the TriNetX database, 53,716 patients with HS were matched to an equivalent number of non-HS controls using propensity score matching. The study covered the period from January 1st, 2005, to December 31st, 2017. Hazard ratios and their respective 95% confidence intervals (CIs), were computed to evaluate the occurrences of keratitis and keratopathy over a 5-year duration in patients with HS, compared to non-HS controls.
RESULTS: HS was associated with a 1.52 times higher risk of keratitis over a 5-year period (95%CI=1.24-1.86) and a 1.47 times higher risk of keratopathy (95%CI=1.18-1.84). These risks remained consistent in sensitivity analyses. The elevated risk of keratitis was observed across both sexes. However, the risk of keratopathy was significantly higher in women with HS (HR=1.61, 95%CI=1.24-2.10) and individuals aged 18-64 years (HR=1.32, 95%CI=1.04-1.68).
CONCLUSIONS: HS was linked to an elevated risk of both keratitis and keratopathy over a 5-year period. Ophthalmologic manifestations are recommended to be considered in HS standard care.
METHODS: In this retrospective cohort study conducted with data from the TriNetX database, 53,716 patients with HS were matched to an equivalent number of non-HS controls using propensity score matching. The study covered the period from January 1st, 2005, to December 31st, 2017. Hazard ratios and their respective 95% confidence intervals (CIs), were computed to evaluate the occurrences of keratitis and keratopathy over a 5-year duration in patients with HS, compared to non-HS controls.
RESULTS: HS was associated with a 1.52 times higher risk of keratitis over a 5-year period (95%CI=1.24-1.86) and a 1.47 times higher risk of keratopathy (95%CI=1.18-1.84). These risks remained consistent in sensitivity analyses. The elevated risk of keratitis was observed across both sexes. However, the risk of keratopathy was significantly higher in women with HS (HR=1.61, 95%CI=1.24-2.10) and individuals aged 18-64 years (HR=1.32, 95%CI=1.04-1.68).
CONCLUSIONS: HS was linked to an elevated risk of both keratitis and keratopathy over a 5-year period. Ophthalmologic manifestations are recommended to be considered in HS standard care.
摘要：
目的：化脓性汗腺炎（HS）与免疫失调和全身性炎症有关。虽然以前的研究表明HS中眼部表现的患病率较高，角膜病变和角膜炎的具体风险尚不清楚.这项研究的主要目的是评估HS患者角膜炎和角膜病变的风险。
方法：在这项使用TriNetX数据库数据进行的回顾性队列研究中，使用倾向评分匹配将53,716例HS患者与同等数量的非HS对照进行匹配。这项研究涵盖了从1月1日开始的时期，2005年12月31日,2017.危险比及其各自的95%置信区间(CI)，计算以评估HS患者在5年内的角膜炎和角膜病变的发生情况，与非HS对照相比。
结果：HS与5年期间的角膜炎风险高1.52倍（95CI=1.24-1.86）和角膜病变风险高1.47倍（95CI=1.18-1.84）相关。这些风险在敏感性分析中保持一致。在两种性别中都观察到角膜炎的风险升高。然而,HS患者(HR=1.61,95CI=1.24~2.10)和18~64岁患者(HR=1.32,95CI=1.04~1.68)的角膜病变风险显著增高.
结论：HS与5年期间角膜炎和角膜病变的风险升高有关。建议在HS标准护理中考虑眼科表现。
方法：在这项使用TriNetX数据库数据进行的回顾性队列研究中，使用倾向评分匹配将53,716例HS患者与同等数量的非HS对照进行匹配。这项研究涵盖了从1月1日开始的时期，2005年12月31日,2017.危险比及其各自的95%置信区间(CI)，计算以评估HS患者在5年内的角膜炎和角膜病变的发生情况，与非HS对照相比。
结果：HS与5年期间的角膜炎风险高1.52倍（95CI=1.24-1.86）和角膜病变风险高1.47倍（95CI=1.18-1.84）相关。这些风险在敏感性分析中保持一致。在两种性别中都观察到角膜炎的风险升高。然而,HS患者(HR=1.61,95CI=1.24~2.10)和18~64岁患者(HR=1.32,95CI=1.04~1.68)的角膜病变风险显著增高.
结论：HS与5年期间角膜炎和角膜病变的风险升高有关。建议在HS标准护理中考虑眼科表现。
