PDF(Pubmed)
Abstract：
OBJECTIVE: Chronic cerebral hypoxia often leads to brain damage and inflammation. Propofol is suggested to have neuroprotective effects under anaesthesia.
METHODS: This study used rat models with carotid artery coarctation or closure. Four groups of rats were compared: a control group, a propofol-treated group, a group with bilateral common carotid artery blockage (BCAO), and a BCAO group treated with propofol post-surgery.
RESULTS: The Morris water maze test indicated cognitive impairment in BCAO rats, which also showed hippocampal structure changes, oxidative stress markers alteration, and reduced Klotho expression. Propofol treatment post-BCAO surgery improved these outcomes, suggesting its potential in mitigating chronic cerebral hypoxia effects.
CONCLUSIONS: Propofol may increase klotho levels and reduce apoptosis and inflammation linked to oxidative stress in cognitively impaired mice.
METHODS: This study used rat models with carotid artery coarctation or closure. Four groups of rats were compared: a control group, a propofol-treated group, a group with bilateral common carotid artery blockage (BCAO), and a BCAO group treated with propofol post-surgery.
RESULTS: The Morris water maze test indicated cognitive impairment in BCAO rats, which also showed hippocampal structure changes, oxidative stress markers alteration, and reduced Klotho expression. Propofol treatment post-BCAO surgery improved these outcomes, suggesting its potential in mitigating chronic cerebral hypoxia effects.
CONCLUSIONS: Propofol may increase klotho levels and reduce apoptosis and inflammation linked to oxidative stress in cognitively impaired mice.
摘要：
目的：慢性脑缺氧常导致脑损伤和炎症。建议丙泊酚在麻醉下具有神经保护作用。
方法：本研究使用颈动脉缩窄或闭合的大鼠模型。比较四组大鼠：对照组，丙泊酚治疗组，一组双侧颈总动脉阻塞（BCAO），和一个BCAO组在手术后接受丙泊酚治疗。
结果：Morris水迷宫实验提示BCAO大鼠认知障碍，这也显示了海马结构的变化，氧化应激标志物改变，并降低了Klotho的表达。丙泊酚治疗BCAO手术后改善了这些结果，提示其减轻慢性脑缺氧影响的潜力。
结论：丙泊酚可增加Klotho水平，减少与氧化应激相关的细胞凋亡和炎症反应。
方法：本研究使用颈动脉缩窄或闭合的大鼠模型。比较四组大鼠：对照组，丙泊酚治疗组，一组双侧颈总动脉阻塞（BCAO），和一个BCAO组在手术后接受丙泊酚治疗。
结果：Morris水迷宫实验提示BCAO大鼠认知障碍，这也显示了海马结构的变化，氧化应激标志物改变，并降低了Klotho的表达。丙泊酚治疗BCAO手术后改善了这些结果，提示其减轻慢性脑缺氧影响的潜力。
结论：丙泊酚可增加Klotho水平，减少与氧化应激相关的细胞凋亡和炎症反应。
