%0 Journal Article
%T The Effect of Propofol on the Hippocampus in Chronic Cerebral Hypoxia in a Rat Model Through Klotho Regulation.
%A Ren H
%A Zhu M
%A Yu H
%A Weng Y
%A Yu W
%J In Vivo
%V 38
%N 3
%D 2024 May-Jun
%M 38688607
%F 2.406
%R 10.21873/invivo.13551
%X <B>OBJECTIVE: </B>Chronic cerebral hypoxia often leads to brain damage and inflammation. Propofol is suggested to have neuroprotective effects under anaesthesia.<BR><B>METHODS: </B>This study used rat models with carotid artery coarctation or closure. Four groups of rats were compared: a control group, a propofol-treated group, a group with bilateral common carotid artery blockage (BCAO), and a BCAO group treated with propofol post-surgery.<BR><B>RESULTS: </B>The Morris water maze test indicated cognitive impairment in BCAO rats, which also showed hippocampal structure changes, oxidative stress markers alteration, and reduced Klotho expression. Propofol treatment post-BCAO surgery improved these outcomes, suggesting its potential in mitigating chronic cerebral hypoxia effects.<BR><B>CONCLUSIONS: </B>Propofol may increase klotho levels and reduce apoptosis and inflammation linked to oxidative stress in cognitively impaired mice.