Abstract：
The applicability of nanomaterials has evolved in biomedical domains thanks to advances in biocompatibility strategies and the mitigation of cytotoxic effects, allowing diagnostics, imaging, and therapeutic approaches. The application of nanoparticles (NP), particularly metal nanoparticles (mNPs), such as gold (Au) and silver (Ag), includes inherent challenges related to the material characteristics, surface modification, and bioconjugation techniques. By tailoring the surface properties through appropriate coating with biocompatible molecules or functionalization with active biomolecules, researchers can reach a harmonious interaction with biological systems or samples (mostly fluids or tissues). Thus, this review highlights the mechanisms associated with the obtention of biocompatible mNP and presents a comprehensive overview of methods that facilitate safe and efficient production. Therefore, we consider this review to be a valuable resource for all researchers navigating this dynamic field.
摘要：
由于生物相容性策略的进步和细胞毒性效应的缓解，纳米材料在生物医学领域的适用性已经发展。允许诊断，成像,和治疗方法。纳米粒子（NP）的应用，特别是金属纳米颗粒(mNP)，如金(Au)和银(Ag)，包括与材料特性相关的固有挑战，表面改性,和生物缀合技术。通过用生物相容性分子进行适当的涂层或用活性生物分子进行功能化来定制表面特性，研究人员可以与生物系统或样品（主要是液体或组织）达成和谐的相互作用。因此，这篇综述重点介绍了与生物相容性mNP获得相关的机制,并对促进安全和高效生产的方法进行了全面概述.因此,我们认为这篇综述是所有研究人员在这个动态领域的宝贵资源。
