Abstract：
BACKGROUND: The distribution of causes of hyperferritinemia in international series is heterogeneous. Also, the association between ferritin and prognosis is controversial. This study aims to describe the diagnosis associated with hyperferritinemia in a retrospective cohort at an academic healthcare network in Chile.
METHODS: A retrospective review of adult patients admitted to our academic medical center from June 2014 to February 2017 with ferritin ≥3,000 ng/mL. All patients were classified into nine diagnostic categories. Then, the association between ferritin level and disease category, as well as mortality, was evaluated.
RESULTS: Ninety-nine patients were identified. The mean age was 50.8 ± 19.9 years, 54.5% were men. The most frequent categories were \"inflammatory and autoimmune diseases\" (21.2%) and \"hematological malignancies\" (19.2%). The average ferritin was 10,539 ± 13,016.9 ng/mL, while the higher mean was 16,707 ng/mL in the \"inflammatory and autoimmune diseases\" category. There was a statistically significant association between the ferritin value and age but not between ferritin and diagnostic categories. In the group over 50, hematologic neoplasms (19%) and infections (19%) were more frequent. In those under 50, inflammatory and autoimmune diseases were more frequent (26.8%). There was no association between the ferritin level and mortality at 1, 3, and 12 months.
CONCLUSIONS: The most frequent categories were \"inflammatory and autoimmune diseases\" and \"hematological malignancies\", but ferritin level was similar in both. Further research could validate a prognostic role.
METHODS: A retrospective review of adult patients admitted to our academic medical center from June 2014 to February 2017 with ferritin ≥3,000 ng/mL. All patients were classified into nine diagnostic categories. Then, the association between ferritin level and disease category, as well as mortality, was evaluated.
RESULTS: Ninety-nine patients were identified. The mean age was 50.8 ± 19.9 years, 54.5% were men. The most frequent categories were \"inflammatory and autoimmune diseases\" (21.2%) and \"hematological malignancies\" (19.2%). The average ferritin was 10,539 ± 13,016.9 ng/mL, while the higher mean was 16,707 ng/mL in the \"inflammatory and autoimmune diseases\" category. There was a statistically significant association between the ferritin value and age but not between ferritin and diagnostic categories. In the group over 50, hematologic neoplasms (19%) and infections (19%) were more frequent. In those under 50, inflammatory and autoimmune diseases were more frequent (26.8%). There was no association between the ferritin level and mortality at 1, 3, and 12 months.
CONCLUSIONS: The most frequent categories were \"inflammatory and autoimmune diseases\" and \"hematological malignancies\", but ferritin level was similar in both. Further research could validate a prognostic role.
摘要：
背景：国际系列高铁蛋白血症的病因分布不均。此外，铁蛋白与预后之间的关联存在争议.本研究旨在描述智利学术医疗保健网络的回顾性队列中与高铁蛋白血症相关的诊断。
方法：回顾性回顾了2014年6月至2017年2月在我们的学术医学中心接受铁蛋白≥3,000ng/mL的成年患者。将所有患者分为9个诊断类别。然后，铁蛋白水平与疾病类别之间的关联，以及死亡率，进行了评估。
结果：确认了99例患者。平均年龄50.8±19.9岁,54.5%是男性。最常见的类别是“炎症和自身免疫性疾病”（21.2％）和“血液恶性肿瘤”（19.2％）。平均铁蛋白为10,539±13,016.9ng/mL，而在“炎症和自身免疫性疾病”类别中，较高的平均值为16,707ng/mL。铁蛋白值与年龄之间存在统计学上的显着关联，但铁蛋白与诊断类别之间没有统计学上的显着关联。在50岁以上的组中，血液肿瘤（19％）和感染（19％）更为频繁。在50岁以下的人群中，炎症和自身免疫性疾病更常见（26.8%）。在1、3和12个月时，铁蛋白水平与死亡率之间没有关联。
结论：最常见的类别是“炎症和自身免疫性疾病”和“血液恶性肿瘤”，但两者的铁蛋白水平相似。进一步的研究可以验证预后作用。
方法：回顾性回顾了2014年6月至2017年2月在我们的学术医学中心接受铁蛋白≥3,000ng/mL的成年患者。将所有患者分为9个诊断类别。然后，铁蛋白水平与疾病类别之间的关联，以及死亡率，进行了评估。
结果：确认了99例患者。平均年龄50.8±19.9岁,54.5%是男性。最常见的类别是“炎症和自身免疫性疾病”（21.2％）和“血液恶性肿瘤”（19.2％）。平均铁蛋白为10,539±13,016.9ng/mL，而在“炎症和自身免疫性疾病”类别中，较高的平均值为16,707ng/mL。铁蛋白值与年龄之间存在统计学上的显着关联，但铁蛋白与诊断类别之间没有统计学上的显着关联。在50岁以上的组中，血液肿瘤（19％）和感染（19％）更为频繁。在50岁以下的人群中，炎症和自身免疫性疾病更常见（26.8%）。在1、3和12个月时，铁蛋白水平与死亡率之间没有关联。
结论：最常见的类别是“炎症和自身免疫性疾病”和“血液恶性肿瘤”，但两者的铁蛋白水平相似。进一步的研究可以验证预后作用。
