Abstract：
OBJECTIVE: To study the etiological characteristics of community-acquired pneumonia (CAP) combined with type 2 diabetes (T2D), providing a reference for early clinical diagnosis and treatment of the disease.
METHODS: We selected a total of 93 patients with CAP and analyzed their metagenomics nextgeneration sequencing (mNGS) data. The case group comprised 46 patients with combined CAP/T2D, and the control group comprised 47 patients without diabetes. We analyzed the pathogenic findings of the two groups.
RESULTS: There were statistically significant differences in age between the two groups (P = 0.001). Leukocytes (P = 0.012), blood platelets (P = 0.034), fibrinogen (P = 0.037), D-dimer (P = 0.000), calcitonin ogen (P = 0.015), ultrasensitive C-reactive protein or C-reactive protein (CRP) (P = 0.000), serum amyloid A (P = 0.000), and erythrocyte sedimentation rate (P = 0.003) were higher in the case group than in the control group. Albumin was lower in the case group than in the control group. All differences were statistically significant. The infection rates of Klebsiella pneumoniae (P = 0.030), Pseudomonas aeruginosa (P = 0.043), and Candida albicans (P = 0.032) were significantly different between the two groups.
CONCLUSIONS: Compared with those without diabetes, the infection rates of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans were higher in patients with combined CAP/T2D.
METHODS: We selected a total of 93 patients with CAP and analyzed their metagenomics nextgeneration sequencing (mNGS) data. The case group comprised 46 patients with combined CAP/T2D, and the control group comprised 47 patients without diabetes. We analyzed the pathogenic findings of the two groups.
RESULTS: There were statistically significant differences in age between the two groups (P = 0.001). Leukocytes (P = 0.012), blood platelets (P = 0.034), fibrinogen (P = 0.037), D-dimer (P = 0.000), calcitonin ogen (P = 0.015), ultrasensitive C-reactive protein or C-reactive protein (CRP) (P = 0.000), serum amyloid A (P = 0.000), and erythrocyte sedimentation rate (P = 0.003) were higher in the case group than in the control group. Albumin was lower in the case group than in the control group. All differences were statistically significant. The infection rates of Klebsiella pneumoniae (P = 0.030), Pseudomonas aeruginosa (P = 0.043), and Candida albicans (P = 0.032) were significantly different between the two groups.
CONCLUSIONS: Compared with those without diabetes, the infection rates of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans were higher in patients with combined CAP/T2D.
摘要：
目的：研究社区获得性肺炎（CAP）合并2型糖尿病（T2D）的病原学特征，为该病的早期临床诊断和治疗提供参考。
方法：我们选择了93例CAP患者，并分析了他们的宏基因组学下一代测序（mNGS）数据。病例组包括46例联合CAP/T2D患者，对照组包括47例无糖尿病患者。我们分析了两组的致病结果。
结果：两组年龄差异有统计学意义（P=0.001）。白细胞（P=0.012），血小板（P=0.034），纤维蛋白原（P=0.037），D-二聚体(P=0.000),降钙素原（P=0.015），超敏C反应蛋白或C反应蛋白(CRP)(P=0.000),血清淀粉样蛋白A(P=0.000),病例组红细胞沉降率(P=0.003)高于对照组。病例组的白蛋白低于对照组。所有差异均有统计学意义。肺炎克雷伯菌感染率(P=0.030),铜绿假单胞菌(P=0.043),和白色念珠菌(P=0.032)两组间差异有统计学意义。
结论：与无糖尿病者相比，肺炎克雷伯菌的感染率，铜绿假单胞菌,CAP/T2D合并患者的白色念珠菌较高。
方法：我们选择了93例CAP患者，并分析了他们的宏基因组学下一代测序（mNGS）数据。病例组包括46例联合CAP/T2D患者，对照组包括47例无糖尿病患者。我们分析了两组的致病结果。
结果：两组年龄差异有统计学意义（P=0.001）。白细胞（P=0.012），血小板（P=0.034），纤维蛋白原（P=0.037），D-二聚体(P=0.000),降钙素原（P=0.015），超敏C反应蛋白或C反应蛋白(CRP)(P=0.000),血清淀粉样蛋白A(P=0.000),病例组红细胞沉降率(P=0.003)高于对照组。病例组的白蛋白低于对照组。所有差异均有统计学意义。肺炎克雷伯菌感染率(P=0.030),铜绿假单胞菌(P=0.043),和白色念珠菌(P=0.032)两组间差异有统计学意义。
结论：与无糖尿病者相比，肺炎克雷伯菌的感染率，铜绿假单胞菌,CAP/T2D合并患者的白色念珠菌较高。
