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Abstract：
BACKGROUND: Methanol-poisoning can be a challenging cause of mortality. Identifying the epidemiological, clinical, and para-clinical determinants of outcome in methanol-poisoning patients could be a step forward to its management.
METHODS: In this hospital-based cohort study, 123 methanol-poisoning patients were included. Data on background variables, details of methanol consumption, and laboratory assessments were recorded for each patient. Patients underwent brain CT scans without contrast. We evaluated the association of all gathered clinical and para-clinical data with patients\' outcome and length of hospital stay (LOS). Independent association of potential determinants of death, and LOS were modeled applying multivariable logistic, and Ordinary Least Square regressions, respectively. Odds ratio (OR), and regression coefficient (RC), and their 95% confidence intervals (CIs) were estimated.
RESULTS: Most of the study population were male (n=107/123). The mean age of the participants was 30.3±9.1 years. Ninety patients (73.2%) were reported as being conscious on admission, and 34.3% of patients were identified with at least one abnormality in their CT scan. Level of consciousness (LOC) (OR: 42.2; 95% CI: 2.35-756.50), and blood pH (OR: 0.37; 95% CI: 0.22-0.65) were associated with death. Supratentorial edema (RC: 17.55; 95% CI: 16.95-18.16) were associated with LOS.
CONCLUSIONS: Besides LOC, patients with any abnormality in their brain CT scan on admission were found to be at higher risk of death, and patients with supratentorial edema were at risk of longer LOS. Brain CT-scan on admission should be considered as a part of the routine procedure during the management of methanol-poisoning.
METHODS: In this hospital-based cohort study, 123 methanol-poisoning patients were included. Data on background variables, details of methanol consumption, and laboratory assessments were recorded for each patient. Patients underwent brain CT scans without contrast. We evaluated the association of all gathered clinical and para-clinical data with patients\' outcome and length of hospital stay (LOS). Independent association of potential determinants of death, and LOS were modeled applying multivariable logistic, and Ordinary Least Square regressions, respectively. Odds ratio (OR), and regression coefficient (RC), and their 95% confidence intervals (CIs) were estimated.
RESULTS: Most of the study population were male (n=107/123). The mean age of the participants was 30.3±9.1 years. Ninety patients (73.2%) were reported as being conscious on admission, and 34.3% of patients were identified with at least one abnormality in their CT scan. Level of consciousness (LOC) (OR: 42.2; 95% CI: 2.35-756.50), and blood pH (OR: 0.37; 95% CI: 0.22-0.65) were associated with death. Supratentorial edema (RC: 17.55; 95% CI: 16.95-18.16) were associated with LOS.
CONCLUSIONS: Besides LOC, patients with any abnormality in their brain CT scan on admission were found to be at higher risk of death, and patients with supratentorial edema were at risk of longer LOS. Brain CT-scan on admission should be considered as a part of the routine procedure during the management of methanol-poisoning.
摘要：
背景：甲醇中毒可能是一个具有挑战性的死亡原因。识别流行病学，临床,和对甲醇中毒患者结局的临床决定因素可能是其管理的一步。
方法：在这项基于医院的队列研究中，包括123例甲醇中毒患者。背景变量的数据，甲醇消耗的详细信息，并记录每位患者的实验室评估.患者接受了无对比的脑部CT扫描。我们评估了所有收集的临床和临床数据与患者预后和住院时间（LOS）的关联。潜在死亡决定因素的独立关联，和LOS采用多变量Logistic建模，和普通最小二乘回归，分别。赔率比(OR)，和回归系数(RC)，并估计了他们的95%置信区间(CI)。
结果：大多数研究人群为男性（n=107/123）。参与者的平均年龄为30.3±9.1岁。90例患者（73.2%）被报告为入院时有意识，34.3%的患者在CT扫描中发现至少有一个异常。意识水平（LOC）（OR：42.2；95％CI：2.35-756.50），血液pH值(OR:0.37;95%CI:0.22-0.65)与死亡相关。幕上水肿（RC：17.55；95％CI：16.95-18.16）与LOS相关。
结论：除了LOC，发现入院时脑CT扫描有任何异常的患者死亡风险较高，幕上水肿患者有较长的LOS风险。在甲醇中毒的管理过程中，入院时的脑部CT扫描应被视为常规程序的一部分。
方法：在这项基于医院的队列研究中，包括123例甲醇中毒患者。背景变量的数据，甲醇消耗的详细信息，并记录每位患者的实验室评估.患者接受了无对比的脑部CT扫描。我们评估了所有收集的临床和临床数据与患者预后和住院时间（LOS）的关联。潜在死亡决定因素的独立关联，和LOS采用多变量Logistic建模，和普通最小二乘回归，分别。赔率比(OR)，和回归系数(RC)，并估计了他们的95%置信区间(CI)。
结果：大多数研究人群为男性（n=107/123）。参与者的平均年龄为30.3±9.1岁。90例患者（73.2%）被报告为入院时有意识，34.3%的患者在CT扫描中发现至少有一个异常。意识水平（LOC）（OR：42.2；95％CI：2.35-756.50），血液pH值(OR:0.37;95%CI:0.22-0.65)与死亡相关。幕上水肿（RC：17.55；95％CI：16.95-18.16）与LOS相关。
结论：除了LOC，发现入院时脑CT扫描有任何异常的患者死亡风险较高，幕上水肿患者有较长的LOS风险。在甲醇中毒的管理过程中，入院时的脑部CT扫描应被视为常规程序的一部分。
