Abstract：
UNASSIGNED: The oral cavity harbors an extensive array of over 700 microorganisms, forming the most complex biome of the entire human body, with bacterial species being the most abundant. Oral diseases, e.g. periodontitis and caries, are strictly associated with bacterial dysbiosis. Porphyromonas gingivalis and Streptococcus mutans stand out among bacteria colonizing the oral cavity.
UNASSIGNED: After a brief overview of the bacterial populations in the oral cavity and their roles in regulating (flora) oral cavity or causing diseases like periodontal and cariogenic pathogens, we focused our attention on P. gingivalis and S. mutans, searching for the last-5-year patents dealing with the proposal of new strategies to fight their infections. Following the PRISMA protocol, we filtered the results and analyzed over 100 applied/granted patents, to provide an in-depth insight into this R&D scenario.
UNASSIGNED: Several antibacterial proposals have been patented in this period, from both chemical - peptides and small molecules - and biological - probiotics and antibodies - sources, along with natural extracts, polymers, and drug delivery systems. Most of the inventors are from China and Korea and their studies also investigated anti-inflammatory and antioxidant effects, being beneficial to oral health through a prophylactic, protective, or curative effect.
UNASSIGNED: After a brief overview of the bacterial populations in the oral cavity and their roles in regulating (flora) oral cavity or causing diseases like periodontal and cariogenic pathogens, we focused our attention on P. gingivalis and S. mutans, searching for the last-5-year patents dealing with the proposal of new strategies to fight their infections. Following the PRISMA protocol, we filtered the results and analyzed over 100 applied/granted patents, to provide an in-depth insight into this R&D scenario.
UNASSIGNED: Several antibacterial proposals have been patented in this period, from both chemical - peptides and small molecules - and biological - probiotics and antibodies - sources, along with natural extracts, polymers, and drug delivery systems. Most of the inventors are from China and Korea and their studies also investigated anti-inflammatory and antioxidant effects, being beneficial to oral health through a prophylactic, protective, or curative effect.
摘要：
■口腔含有700多种微生物，形成了整个人体最复杂的生物群落，细菌种类最丰富。口腔疾病,例如牙周炎和龋齿，与细菌菌群失调密切相关。牙龈卟啉单胞菌和变形链球菌在定植于口腔的细菌中脱颖而出。
■在简要概述了口腔中的细菌种群及其在调节（菌群）口腔或引起牙周和致龋病原体等疾病中的作用之后，我们把注意力集中在牙龈卟啉单胞菌和变形链球菌上，寻找过去5年的专利，以处理新的策略来对抗他们的感染的建议。按照PRISMA协议,我们过滤了结果并分析了100多项申请/授权专利，提供对这一研发场景的深入洞察。
■在此期间，一些抗菌提案已获得专利，来自化学-肽和小分子-以及生物-益生菌和抗体-来源，以及天然提取物，聚合物，和药物输送系统。大多数发明人来自中国和韩国，他们的研究还研究了抗炎和抗氧化作用，通过预防对口腔健康有益，保护,或疗效。
■在简要概述了口腔中的细菌种群及其在调节（菌群）口腔或引起牙周和致龋病原体等疾病中的作用之后，我们把注意力集中在牙龈卟啉单胞菌和变形链球菌上，寻找过去5年的专利，以处理新的策略来对抗他们的感染的建议。按照PRISMA协议,我们过滤了结果并分析了100多项申请/授权专利，提供对这一研发场景的深入洞察。
■在此期间，一些抗菌提案已获得专利，来自化学-肽和小分子-以及生物-益生菌和抗体-来源，以及天然提取物，聚合物，和药物输送系统。大多数发明人来自中国和韩国，他们的研究还研究了抗炎和抗氧化作用，通过预防对口腔健康有益，保护,或疗效。
