关键词: Chemotherapy Dentistry and oral medicine Head and neck cancer Pathology Therapeutic indications

Mesh : Female Humans Male Adenocarcinoma, Clear Cell / secondary therapy pathology drug therapy Antineoplastic Combined Chemotherapy Protocols / therapeutic use Immunotherapy / methods Lung Neoplasms / pathology drug therapy therapy Maxillary Neoplasms / drug therapy pathology diagnostic imaging Odontogenic Tumors / pathology drug therapy diagnostic imaging Aged

来  源:   DOI:10.1136/bcr-2023-259568   PDF(Pubmed)

Abstract:
Our patient initially presented with 6 months of left jaw pain and gingival bleeding, leading to the discovery of a radiolucent left maxillary mass on dental evaluation. A biopsy confirmed clear cell odontogenic carcinoma, and the patient was treated with definitive surgery and radiation for localised disease. Unfortunately, the patient was found to have pulmonary metastases 3 months after initial management and was subsequently treated with a combination of cytotoxic chemotherapy and immunotherapy with a partial response. To our knowledge, this is the first case demonstrating the successful use of chemoimmunotherapy in metastatic clear cell odontogenic carcinoma.
摘要:
我们的患者最初表现为6个月的左颌疼痛和牙龈出血,导致在牙科评估中发现放射性可见的左上颌肿块。活检证实透明细胞牙源性癌,患者接受了确定性手术和放射治疗,以治疗局部疾病。不幸的是,患者在初次治疗3个月后发现肺转移,随后接受细胞毒性化疗和免疫疗法联合治疗,部分缓解.据我们所知,这是第一例证明在转移性透明细胞牙源性癌中成功使用化学免疫疗法的病例。
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