PDF(Pubmed)
Abstract：
Previous registries have shown a younger average age at presentation with cardiovascular diseases in the Middle East (ME), but no study has examined atrioventricular block (AVB). Moreover, these comparisons are confounded by younger populations in the ME. We sought to describe the average age at presentation with AVB in ME and quantify the effect of being from ME, adjusted for the overall younger population.
This was a retrospective analysis of PANORAMA registries, which collected data on patients who underwent cardiac rhythm device placement worldwide. Countries with a median population age of ≤30 were considered \'young countries\'. Multivariate linear regression was performed to assess the effect of being from ME, adjusted for being from a \'young country\', on age at presentation with AVB.
The study included 5,259 AVB patients, with 640 (8.2%) from the ME. Mean age at presentation was seven years younger in ME than in other regions (62.9 ± 17.8 vs. 70 ± 14.1, P < 0.001). Being from a \'young country\' was associated with 5.6 years younger age at presentation (95%CI -6.5--4.6), whereas being from ME was associated with 3.1 years younger age at presentation (95%CI -4.5--1.8), (P < 0.001 for both).
The average age at presentation with AVB in the ME is seven years younger than in other regions. While this is mostly driven by the overall younger population, being from the ME appears to be independently associated with younger age. Determinants of the earlier presentation in ME need to be assessed, and care should be taken when applying international recommendations.
This was a retrospective analysis of PANORAMA registries, which collected data on patients who underwent cardiac rhythm device placement worldwide. Countries with a median population age of ≤30 were considered \'young countries\'. Multivariate linear regression was performed to assess the effect of being from ME, adjusted for being from a \'young country\', on age at presentation with AVB.
The study included 5,259 AVB patients, with 640 (8.2%) from the ME. Mean age at presentation was seven years younger in ME than in other regions (62.9 ± 17.8 vs. 70 ± 14.1, P < 0.001). Being from a \'young country\' was associated with 5.6 years younger age at presentation (95%CI -6.5--4.6), whereas being from ME was associated with 3.1 years younger age at presentation (95%CI -4.5--1.8), (P < 0.001 for both).
The average age at presentation with AVB in the ME is seven years younger than in other regions. While this is mostly driven by the overall younger population, being from the ME appears to be independently associated with younger age. Determinants of the earlier presentation in ME need to be assessed, and care should be taken when applying international recommendations.
摘要：
■以前的登记册显示，中东（ME）患有心血管疾病的平均年龄较年轻，但没有研究检查房室传导阻滞（AVB）。此外，这些比较与ME的年轻人群混淆.我们试图描述ME中AVB的平均年龄，并量化来自ME的影响，根据总体年轻人口进行了调整。
■这是对PANORAMA注册管理机构的回顾性分析，它收集了全球接受心律装置放置的患者的数据。人口年龄中位数≤30岁的国家被认为是“年轻国家”。进行多元线性回归以评估来自ME的影响，适应于来自一个“年轻的国家”，关于AVB演示的年龄。
■该研究包括5,259名AVB患者，640人（8.2%）来自ME。ME的平均年龄比其他地区年轻7岁（62.9±17.8与70±14.1,P<0.001)。来自“年轻国家”的人在演示时与5.6岁的年龄有关（95CI-6.5--4.6），而来自ME的患者在就诊时年龄较小3.1岁(95CI-4.5--1.8)，（两者P<0.001）。
■在ME中出现AVB的平均年龄比其他地区小7岁。虽然这主要是由整体年轻人口驱动的，来自ME似乎与年轻年龄独立相关。需要评估ME早期陈述的决定因素，在应用国际建议时应该小心。
■这是对PANORAMA注册管理机构的回顾性分析，它收集了全球接受心律装置放置的患者的数据。人口年龄中位数≤30岁的国家被认为是“年轻国家”。进行多元线性回归以评估来自ME的影响，适应于来自一个“年轻的国家”，关于AVB演示的年龄。
■该研究包括5,259名AVB患者，640人（8.2%）来自ME。ME的平均年龄比其他地区年轻7岁（62.9±17.8与70±14.1,P<0.001)。来自“年轻国家”的人在演示时与5.6岁的年龄有关（95CI-6.5--4.6），而来自ME的患者在就诊时年龄较小3.1岁(95CI-4.5--1.8)，（两者P<0.001）。
■在ME中出现AVB的平均年龄比其他地区小7岁。虽然这主要是由整体年轻人口驱动的，来自ME似乎与年轻年龄独立相关。需要评估ME早期陈述的决定因素，在应用国际建议时应该小心。
