PDF(Pubmed)
Abstract：
Dimethyl sulfate (DMS) is a drug widely used as a pharmaceutical and synthetic raw material. On the other hand, it is highly toxic and requires management and treatment as a hazardous substance. A mass outbreak of chemical burns resulting from DMS poisoning occurred at a drug factory. All three patients were brought to our hospital, a tertiary emergency medical facility, several hours after exposure. Their vital signs were stable, with only eye pain and a sore throat. However, after admission, two patients required emergency tracheostomy or endotracheal intubation due to laryngeal edema. Improvement was achieved through the administration of steroids, but a severely injured patient required an extended treatment period. DMS poisoning is rare; however, it can be fatal depending on the exposure concentration. Furthermore, even if the initial symptoms are mild, laryngeal edema may develop later, requiring careful monitoring and appropriate airway interventions.
摘要：
硫酸二甲酯(DMS)是一种广泛用作药物和合成原料的药物。另一方面,它具有剧毒性，需要作为有害物质进行管理和治疗。一家药厂发生了由DMS中毒引起的大规模化学烧伤。三个病人都被送到我们医院,三级紧急医疗设施，几个小时后暴露。他们的生命体征稳定,只有眼睛疼痛和喉咙痛。然而,入院后,两名患者因喉水肿需要紧急气管切开术或气管插管。通过服用类固醇来实现改善，但是一个严重受伤的病人需要延长治疗时间。DMS中毒是罕见的;然而,它可能是致命的，这取决于暴露浓度。此外，即使最初的症状很轻微，喉水肿可能会在以后发展，需要仔细监测和适当的气道干预。
