PDF(Pubmed)
Abstract：
UNASSIGNED: Inflammatory cytokines (ICs) play an important role in erectile dysfunction (ED). Previous studies have demonstrated that most ED patients have high levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8). The causality between 41 ICs and ED is investigated using the Mendelian randomization (MR) approach.
UNASSIGNED: Single nucleotide polymorphisms (SNPs) exposure data of 41 ICs came from a genome-wide association study (GWAS) of 8293 subjects. At the same time, the FINNGEN R9 database provided the ED outcome data containing 2205 ED patients and 164104 controls. MR-Egger (ME), inverse variance weighting (IVW), and weighted median (WM) were applied to conduct the MR study and IVW was taken as the main criterion.
UNASSIGNED: From a genetic perspective, the increase of interferon-inducible protein-10 (IP-10) level significantly increased the risk of ED (P=0.043, odds ratio (OR)=1.269, 95% confidence interval (95%CI): 1.007-1.600), while the increase of interleukin-1 receptor antagonist (IL-1RA) markedly decreased the risk of ED (P=0.037, OR=0.768, 95%CI: 0.600-0.984). Meanwhile, IP-10 (p=0.099) and IL-1RA (p=0.135) failed to demonstrate causality in reverse MR analysis.
UNASSIGNED: Changes in ICs levels will significantly affect the risk of ED, especially IP-10 as a risk component for ED and IL-1RA as a protective component for ED. In the future, we can achieve targeted treatment and prevention of ED by intervening with specific inflammatory factors.
UNASSIGNED: Single nucleotide polymorphisms (SNPs) exposure data of 41 ICs came from a genome-wide association study (GWAS) of 8293 subjects. At the same time, the FINNGEN R9 database provided the ED outcome data containing 2205 ED patients and 164104 controls. MR-Egger (ME), inverse variance weighting (IVW), and weighted median (WM) were applied to conduct the MR study and IVW was taken as the main criterion.
UNASSIGNED: From a genetic perspective, the increase of interferon-inducible protein-10 (IP-10) level significantly increased the risk of ED (P=0.043, odds ratio (OR)=1.269, 95% confidence interval (95%CI): 1.007-1.600), while the increase of interleukin-1 receptor antagonist (IL-1RA) markedly decreased the risk of ED (P=0.037, OR=0.768, 95%CI: 0.600-0.984). Meanwhile, IP-10 (p=0.099) and IL-1RA (p=0.135) failed to demonstrate causality in reverse MR analysis.
UNASSIGNED: Changes in ICs levels will significantly affect the risk of ED, especially IP-10 as a risk component for ED and IL-1RA as a protective component for ED. In the future, we can achieve targeted treatment and prevention of ED by intervening with specific inflammatory factors.
摘要：
■炎性细胞因子（IC）在勃起功能障碍（ED）中起重要作用。以前的研究表明，大多数ED患者有高水平的肿瘤坏死因子-α（TNF-α），白细胞介素-6（IL-6）和白细胞介素-8（IL-8）。使用孟德尔随机化（MR）方法研究了41个IC和ED之间的因果关系。
■41个IC的单核苷酸多态性（SNP）暴露数据来自8293个受试者的全基因组关联研究（GWAS）。同时,FINNGENR9数据库提供了包含2205例ED患者和164104例对照的ED结局数据.MR-Egger(ME),方差逆加权(IVW)，和加权中位数（WM）用于进行MR研究，以IVW为主要标准。
■从遗传的角度来看，干扰素诱导蛋白-10（IP-10）水平的升高显著增加ED的风险（P=0.043，比值比（OR）=1.269，95％置信区间（95CI）：1.007-1.600），而白细胞介素-1受体拮抗剂（IL-1RA）的增加显着降低了ED的风险（P=0.037，OR=0.768，95CI：0.600-0.984）。同时,IP-10（p=0.099）和IL-1RA（p=0.135）在反向MR分析中未能证明因果关系。
■IC水平的变化将显著影响ED的风险，特别是IP-10作为ED的风险成分和IL-1RA作为ED的保护成分。在未来,通过对特定炎症因子的干预,可以实现对ED的针对性治疗和预防。
■41个IC的单核苷酸多态性（SNP）暴露数据来自8293个受试者的全基因组关联研究（GWAS）。同时,FINNGENR9数据库提供了包含2205例ED患者和164104例对照的ED结局数据.MR-Egger(ME),方差逆加权(IVW)，和加权中位数（WM）用于进行MR研究，以IVW为主要标准。
■从遗传的角度来看，干扰素诱导蛋白-10（IP-10）水平的升高显著增加ED的风险（P=0.043，比值比（OR）=1.269，95％置信区间（95CI）：1.007-1.600），而白细胞介素-1受体拮抗剂（IL-1RA）的增加显着降低了ED的风险（P=0.037，OR=0.768，95CI：0.600-0.984）。同时,IP-10（p=0.099）和IL-1RA（p=0.135）在反向MR分析中未能证明因果关系。
■IC水平的变化将显著影响ED的风险，特别是IP-10作为ED的风险成分和IL-1RA作为ED的保护成分。在未来,通过对特定炎症因子的干预,可以实现对ED的针对性治疗和预防。
