PDF(Pubmed)
Abstract：
The recent identification of skull bone marrow as a reactive hematopoietic niche that can contribute to and direct leukocyte trafficking into the meninges and brain has transformed our view of this bone structure from a solid, protective casing to a living, dynamic tissue poised to modulate brain homeostasis and neuroinflammation. This emerging concept may be highly relevant to injuries that directly impact the skull such as in traumatic brain injury (TBI). From mild concussion to severe contusion with skull fracturing, the bone marrow response of this local myeloid cell reservoir has the potential to impact not just the acute inflammatory response in the brain, but also the remodeling of the calvarium itself, influencing its response to future head impacts. If we borrow understanding from recent discoveries in other CNS immunological niches and extend them to this nascent, but growing, subfield of neuroimmunology, it is not unreasonable to consider the hematopoietic compartment in the skull may similarly play an important role in health, aging, and neurodegenerative disease following TBI. This literature review briefly summarizes the traditional role of the skull in TBI and offers some additional insights into skull-brain interactions and their potential role in affecting secondary neuroinflammation and injury outcomes.
摘要：
最近发现颅骨骨髓是一种反应性造血小生境，可以促进并直接将白细胞运输到脑膜和大脑中，这改变了我们对这种骨骼结构的看法，保护一个生命的外壳，动态组织有望调节脑稳态和神经炎症。这种新出现的概念可能与直接影响颅骨的损伤高度相关，例如在创伤性脑损伤（TBI）中。从轻度脑震荡到严重挫伤合并颅骨骨折,这种局部骨髓细胞储库的骨髓反应有可能不仅影响大脑中的急性炎症反应，还有颅骨本身的重塑，影响其对未来头部影响的反应。如果我们借用其他中枢神经系统免疫生态位的最新发现并将其扩展到这个新生时期，但成长，神经免疫学子领域，认为颅骨中的造血隔室可能同样在健康中起重要作用并不是不合理的，老化，和TBI后的神经退行性疾病。这篇文献综述简要总结了颅骨在TBI中的传统作用，并提供了一些关于颅脑相互作用及其在影响继发性神经炎症和损伤结果中的潜在作用的额外见解。
