PDF(Pubmed)
Abstract：
UNASSIGNED: The association between schizophrenia and toxoplasmosis has been demonstrated in a number of studies: the prevalence of schizophrenia is significantly higher in toxoplasmosis positive subjects than in those with T. gondii negative status. However, the clinical significance of this association remains poorly understood.
UNASSIGNED: To identify clinical phenomena that are typical for toxoplasmosis-associated (T. gondii seropositive) schizophrenia compared to Toxoplasma-seronegative schizophrenia.
UNASSIGNED: A retrospective database analysis of serum samples from 105 inpatients with schizophrenia (ICD-10code: F20; including 55 male patients; mean age of 27.4 6.4 years) was carried out. The clinical examination involved a structured interview including ICD-10 and E. Bleulers criteria for schizophrenia and psychometric tests(Positive and Negative Scales of PANSS). Serum antibodies (IgG) to T. gondii were identified using ELISA. The statistical significance of any differences were evaluated using the non-parametric Mann-Whitney (U) and X2 tests.
UNASSIGNED: The proportion of seropositive patients in the sample was 16.2%. Comparing schizophrenia patients, who were seropositive or seronegative for toxoplasmosis, there were no statistically significant differences for the mean total PANSS score, mean PANSS-P, PANSS-N or PANSS-G scores. For the majority of PANSS items, differences were also statistically insignificant, except for G5 and G6mannerism and posturing. Seropositive patients had a higher score for this item than seronegative patients: 3.5 versus 2.1 points (U=389.5; р=0.001). Depression, on the contrary,was less pronounced in seropositive than seronegative patients: 1.4 versus 2.4 points (U=509.5; р=0.023). In addition,in seropositive patients, the frequency of symptoms such as mutism according to ICD-10 criteria for schizophrenia was significantly higher (23.5% versus 3.4%, X2=9.27, р=0.013), and the whole group of catatonic symptoms according to the E. Bleulers criteria for schizophrenia was higher (52.9% versus 28.4%, X2=3.916, p = 0.048).
UNASSIGNED: The association between a positive toxoplasmosis status in patients with schizophrenia and catatonic symptoms has been revealed for the first time and should be verified in larger studies.
UNASSIGNED: To identify clinical phenomena that are typical for toxoplasmosis-associated (T. gondii seropositive) schizophrenia compared to Toxoplasma-seronegative schizophrenia.
UNASSIGNED: A retrospective database analysis of serum samples from 105 inpatients with schizophrenia (ICD-10code: F20; including 55 male patients; mean age of 27.4 6.4 years) was carried out. The clinical examination involved a structured interview including ICD-10 and E. Bleulers criteria for schizophrenia and psychometric tests(Positive and Negative Scales of PANSS). Serum antibodies (IgG) to T. gondii were identified using ELISA. The statistical significance of any differences were evaluated using the non-parametric Mann-Whitney (U) and X2 tests.
UNASSIGNED: The proportion of seropositive patients in the sample was 16.2%. Comparing schizophrenia patients, who were seropositive or seronegative for toxoplasmosis, there were no statistically significant differences for the mean total PANSS score, mean PANSS-P, PANSS-N or PANSS-G scores. For the majority of PANSS items, differences were also statistically insignificant, except for G5 and G6mannerism and posturing. Seropositive patients had a higher score for this item than seronegative patients: 3.5 versus 2.1 points (U=389.5; р=0.001). Depression, on the contrary,was less pronounced in seropositive than seronegative patients: 1.4 versus 2.4 points (U=509.5; р=0.023). In addition,in seropositive patients, the frequency of symptoms such as mutism according to ICD-10 criteria for schizophrenia was significantly higher (23.5% versus 3.4%, X2=9.27, р=0.013), and the whole group of catatonic symptoms according to the E. Bleulers criteria for schizophrenia was higher (52.9% versus 28.4%, X2=3.916, p = 0.048).
UNASSIGNED: The association between a positive toxoplasmosis status in patients with schizophrenia and catatonic symptoms has been revealed for the first time and should be verified in larger studies.
摘要：
■精神分裂症与弓形虫病之间的关联已在许多研究中得到证实：弓形虫病阳性受试者的精神分裂症患病率明显高于弓形虫病阴性受试者。然而,这种关联的临床意义仍然知之甚少.
■确定弓形虫相关的典型临床现象(T.gondii血清阳性）精神分裂症与弓形虫血清阴性精神分裂症相比。
■对105名住院精神分裂症患者（ICD-10代码：F20；包括55名男性患者；平均年龄27.4-6.4岁）的血清样本进行了回顾性数据库分析。临床检查涉及结构化访谈，包括ICD-10和E.Bleulers精神分裂症标准和心理测验（PANSS的阳性和阴性量表）。使用ELISA鉴定针对弓形虫的血清抗体(IgG)。使用非参数Mann-Whitney(U)和X2检验评价任何差异的统计学显著性。
■样本中血清阳性患者的比例为16.2％。比较精神分裂症患者，弓形虫病血清阳性或血清阴性的人，PANSS平均总分无统计学差异，平均PANSS-P，PANSS-N或PANSS-G评分。对于大多数PANSS项目，差异在统计学上也是不显著的，除了G5和G6的举止和姿态。血清反应阳性的患者比血清反应阴性的患者有更高的评分：3.5分和2.1分（U=389.5;C.2=0.001）。抑郁症,相反,与血清阴性患者相比，在血清阳性患者中不太明显：1.4分与2.4分（U=509.5;C.2=0.023）。此外,在血清阳性患者中，根据精神分裂症的ICD-10标准，如mutism等症状的频率明显更高(23.5%对3.4%，X2=9.27,C.2=0.013),根据精神分裂症的E.Bleulers标准，整组的紧张性症状较高（52.9%对28.4%，X2=3.916,p=0.048)。
■精神分裂症患者弓形虫病阳性状态与紧张性症状之间的关联首次被揭示，应在更大的研究中得到证实。
■确定弓形虫相关的典型临床现象(T.gondii血清阳性）精神分裂症与弓形虫血清阴性精神分裂症相比。
■对105名住院精神分裂症患者（ICD-10代码：F20；包括55名男性患者；平均年龄27.4-6.4岁）的血清样本进行了回顾性数据库分析。临床检查涉及结构化访谈，包括ICD-10和E.Bleulers精神分裂症标准和心理测验（PANSS的阳性和阴性量表）。使用ELISA鉴定针对弓形虫的血清抗体(IgG)。使用非参数Mann-Whitney(U)和X2检验评价任何差异的统计学显著性。
■样本中血清阳性患者的比例为16.2％。比较精神分裂症患者，弓形虫病血清阳性或血清阴性的人，PANSS平均总分无统计学差异，平均PANSS-P，PANSS-N或PANSS-G评分。对于大多数PANSS项目，差异在统计学上也是不显著的，除了G5和G6的举止和姿态。血清反应阳性的患者比血清反应阴性的患者有更高的评分：3.5分和2.1分（U=389.5;C.2=0.001）。抑郁症,相反,与血清阴性患者相比，在血清阳性患者中不太明显：1.4分与2.4分（U=509.5;C.2=0.023）。此外,在血清阳性患者中，根据精神分裂症的ICD-10标准，如mutism等症状的频率明显更高(23.5%对3.4%，X2=9.27,C.2=0.013),根据精神分裂症的E.Bleulers标准，整组的紧张性症状较高（52.9%对28.4%，X2=3.916,p=0.048)。
■精神分裂症患者弓形虫病阳性状态与紧张性症状之间的关联首次被揭示，应在更大的研究中得到证实。
