Abstract：
BACKGROUND: Biological rhythms denote the cyclical patterns of life activities anchored to a 24-hour cycle. Research shows that depression exhibits disturbances in biological rhythms. Yet, the relationship between these biological rhythms and concomitant anxiety symptoms is insufficiently investigated in structured clinical assessments.
METHODS: This multicenter study, carried out in four Chinese hospitals, comprehensively examined the relationship between anxiety and disruptions in biological rhythms among patients with depression. The study encompassed 218 patients diagnosed with depression and 205 matched healthy controls. The Chinese version of the Biological Rhythms Interview of Assessment in Neuropsychiatry was utilized to evaluate the participants\' biological rhythms, focusing on four dimensions: sleep, activity, social, and diet.
RESULTS: In patients with depression, there is a significant positive correlation between the severity of anxiety symptoms and the disturbances in biological rhythms. The severity of anxiety and depression, along with the quality of life, are independently associated with disruptions in biological rhythms. The mediation model reveals that anxiety symptoms mediate the relationship between depressive symptoms and biological rhythms.
CONCLUSIONS: This research highlights the role of anxiety within the spectrum of depressive disorders and the associated disturbances in biological rhythms. Our findings shed light on potential pathways towards more targeted preventive strategies and therapeutic interventions for individuals battling depression and anxiety.
METHODS: This multicenter study, carried out in four Chinese hospitals, comprehensively examined the relationship between anxiety and disruptions in biological rhythms among patients with depression. The study encompassed 218 patients diagnosed with depression and 205 matched healthy controls. The Chinese version of the Biological Rhythms Interview of Assessment in Neuropsychiatry was utilized to evaluate the participants\' biological rhythms, focusing on four dimensions: sleep, activity, social, and diet.
RESULTS: In patients with depression, there is a significant positive correlation between the severity of anxiety symptoms and the disturbances in biological rhythms. The severity of anxiety and depression, along with the quality of life, are independently associated with disruptions in biological rhythms. The mediation model reveals that anxiety symptoms mediate the relationship between depressive symptoms and biological rhythms.
CONCLUSIONS: This research highlights the role of anxiety within the spectrum of depressive disorders and the associated disturbances in biological rhythms. Our findings shed light on potential pathways towards more targeted preventive strategies and therapeutic interventions for individuals battling depression and anxiety.
摘要：
背景：生物节律表示以24小时为周期的生命活动的周期性模式。研究表明，抑郁症表现出生物节律的紊乱。然而，这些生物节律与伴随焦虑症状之间的关系在结构化临床评估中没有得到充分研究.
方法：这项多中心研究，在四家中国医院进行，全面检查了抑郁症患者的焦虑与生物节律中断之间的关系。该研究包括218名被诊断患有抑郁症的患者和205名匹配的健康对照。使用中文版的神经精神病学生物节律评估访谈来评估参与者的生物节律，关注四个维度:睡眠，活动,社会,和饮食。
结果：在抑郁症患者中，焦虑症状的严重程度与生物节律紊乱之间存在显着正相关。焦虑和抑郁的严重程度，随着生活的质量，与生物节律的破坏独立相关。中介模型揭示了焦虑症状介导抑郁症状与生物节律之间的关系。
结论：这项研究强调了焦虑在抑郁障碍和相关生物节律紊乱中的作用。我们的发现揭示了针对与抑郁和焦虑作斗争的个体的更有针对性的预防策略和治疗干预的潜在途径。
方法：这项多中心研究，在四家中国医院进行，全面检查了抑郁症患者的焦虑与生物节律中断之间的关系。该研究包括218名被诊断患有抑郁症的患者和205名匹配的健康对照。使用中文版的神经精神病学生物节律评估访谈来评估参与者的生物节律，关注四个维度:睡眠，活动,社会,和饮食。
结果：在抑郁症患者中，焦虑症状的严重程度与生物节律紊乱之间存在显着正相关。焦虑和抑郁的严重程度，随着生活的质量，与生物节律的破坏独立相关。中介模型揭示了焦虑症状介导抑郁症状与生物节律之间的关系。
结论：这项研究强调了焦虑在抑郁障碍和相关生物节律紊乱中的作用。我们的发现揭示了针对与抑郁和焦虑作斗争的个体的更有针对性的预防策略和治疗干预的潜在途径。
