Thbs1 以 TGF β - Smad2 / 3 - ATF4 依赖性方式调节骨骼肌质量。
关键词: ATF4 CP: Metabolism TGFβ atrophy autophagy extracellular matrix proteasome skeletal muscle thrombospondin
Mesh : Animals Male Mice Activating Transcription Factor 4 / metabolism Autophagy Mice, Inbred C57BL Mice, Transgenic Muscle, Skeletal / metabolism pathology Muscular Atrophy / metabolism pathology Signal Transduction Smad2 Protein / metabolism Smad3 Protein / metabolism Thrombospondin 1 / metabolism genetics Transforming Growth Factor beta / metabolism
来 源:
DOI:10.1016/j.celrep.2024.114149
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