PDF(Pubmed)
Abstract：
OBJECTIVE: The connection between triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio and stroke risk is controversial. Our goal was to explore this relationship in individuals aged 45 and older enrolled in the China Health and Retirement Longitudinal Study (CHARLS).
METHODS: Our analysis encompassed 10,164 participants from the CHARLS cohorts. We applied the Cox proportional-hazards regression model to evaluate the potential correlation between the TG/HDL-C ratio and stroke incidence. Using a cubic spline function and smooth curve fitting within the Cox model allowed us to unearth a possible non-linear pattern in this relationship. We also conducted thorough sensitivity and subgroup analyses to deepen our understanding of the TG/HDL-C ratio\'s impact on stroke risk.
RESULTS: Adjusting for various risk factors, we observed a significant link between the TG/HDL-C ratio and increased stroke risk in individuals aged 45 and above (HR: 1.03, 95% CI 1.00-1.05, P = 0.0426). The relationship appeared non-linear, with an inflection at a TG/HDL-C ratio of 1.85. Ratios below this threshold indicated a heightened stroke risk (HR: 1.28, 95% CI 1.06-1.54, P = 0.0089), while ratios above it did not show a significant risk increase (HR: 1.01, 95% CI 0.98-1.04, P = 0.6738). Sensitivity analysis confirmed the robustness of these findings. Notably, non-smokers exhibited a stronger correlation between the TG/HDL-C ratio and stroke risk compared to past and current smokers.
CONCLUSIONS: Our investigation revealed a significant, yet non-linear, association between the TG/HDL-C ratio and the incidence of stroke among individuals aged 45 and above. Specifically, we found that stroke risk increased in correlation with TG/HDL-C ratio below the threshold of 1.85. These insights may guide healthcare providers in advising and developing more effective strategies for stroke prevention in this demographic.
METHODS: Our analysis encompassed 10,164 participants from the CHARLS cohorts. We applied the Cox proportional-hazards regression model to evaluate the potential correlation between the TG/HDL-C ratio and stroke incidence. Using a cubic spline function and smooth curve fitting within the Cox model allowed us to unearth a possible non-linear pattern in this relationship. We also conducted thorough sensitivity and subgroup analyses to deepen our understanding of the TG/HDL-C ratio\'s impact on stroke risk.
RESULTS: Adjusting for various risk factors, we observed a significant link between the TG/HDL-C ratio and increased stroke risk in individuals aged 45 and above (HR: 1.03, 95% CI 1.00-1.05, P = 0.0426). The relationship appeared non-linear, with an inflection at a TG/HDL-C ratio of 1.85. Ratios below this threshold indicated a heightened stroke risk (HR: 1.28, 95% CI 1.06-1.54, P = 0.0089), while ratios above it did not show a significant risk increase (HR: 1.01, 95% CI 0.98-1.04, P = 0.6738). Sensitivity analysis confirmed the robustness of these findings. Notably, non-smokers exhibited a stronger correlation between the TG/HDL-C ratio and stroke risk compared to past and current smokers.
CONCLUSIONS: Our investigation revealed a significant, yet non-linear, association between the TG/HDL-C ratio and the incidence of stroke among individuals aged 45 and above. Specifically, we found that stroke risk increased in correlation with TG/HDL-C ratio below the threshold of 1.85. These insights may guide healthcare providers in advising and developing more effective strategies for stroke prevention in this demographic.
摘要：
目的：甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值与卒中风险之间的联系存在争议。我们的目标是在参加中国健康与退休纵向研究（CHARLS）的45岁及以上人群中探索这种关系。
方法：我们的分析涵盖了来自CHARLS队列的10,164名参与者。我们应用Cox比例风险回归模型来评估TG/HDL-C比值与卒中发生率之间的潜在相关性。在Cox模型中使用三次样条函数和平滑曲线拟合，使我们能够在这种关系中发现可能的非线性模式。我们还进行了全面的敏感性和亚组分析，以加深我们对TG/HDL-C比值对卒中风险影响的理解。
结果：调整各种风险因素，我们观察到45岁及以上人群中TG/HDL-C比值与卒中风险增加之间存在显著联系(HR:1.03,95%CI1.00-1.05,P=0.0426).这种关系似乎是非线性的，TG/HDL-C比率为1.85时出现拐点。低于该阈值的比率表明卒中风险升高(HR:1.28,95%CI1.06-1.54,P=0.0089),而高于它的比率没有显示出显著的风险增加(HR:1.01,95%CI0.98-1.04,P=0.6738)。敏感性分析证实了这些发现的稳健性。值得注意的是,与过去和现在的吸烟者相比,非吸烟者的TG/HDL-C比值与卒中风险之间的相关性更强.
结论：我们的调查显示，然而非线性的，TG/HDL-C比值与45岁及以上人群卒中发生率的相关性.具体来说,我们发现卒中风险与TG/HDL-C比值低于阈值1.85相关.这些见解可能会指导医疗保健提供者在此人口统计学中建议和开发更有效的中风预防策略。
方法：我们的分析涵盖了来自CHARLS队列的10,164名参与者。我们应用Cox比例风险回归模型来评估TG/HDL-C比值与卒中发生率之间的潜在相关性。在Cox模型中使用三次样条函数和平滑曲线拟合，使我们能够在这种关系中发现可能的非线性模式。我们还进行了全面的敏感性和亚组分析，以加深我们对TG/HDL-C比值对卒中风险影响的理解。
结果：调整各种风险因素，我们观察到45岁及以上人群中TG/HDL-C比值与卒中风险增加之间存在显著联系(HR:1.03,95%CI1.00-1.05,P=0.0426).这种关系似乎是非线性的，TG/HDL-C比率为1.85时出现拐点。低于该阈值的比率表明卒中风险升高(HR:1.28,95%CI1.06-1.54,P=0.0089),而高于它的比率没有显示出显著的风险增加(HR:1.01,95%CI0.98-1.04,P=0.6738)。敏感性分析证实了这些发现的稳健性。值得注意的是,与过去和现在的吸烟者相比,非吸烟者的TG/HDL-C比值与卒中风险之间的相关性更强.
结论：我们的调查显示，然而非线性的，TG/HDL-C比值与45岁及以上人群卒中发生率的相关性.具体来说,我们发现卒中风险与TG/HDL-C比值低于阈值1.85相关.这些见解可能会指导医疗保健提供者在此人口统计学中建议和开发更有效的中风预防策略。
