Abstract：
Multimorbidity, i.e., two or more non-communicable diseases (NCDs), is an escalating challenge for society. Venous thromboembolism (VTE) is a common cardiovascular disease and it is unknown which multimorbidity clusters associates with VTE. Our aim was to examine the association between different common disease clusters of multimorbidity and VTE. The study is an extended (1997-2015) cross-sectional Swedish study using the National Patient Register and the Multigeneration Register. A total of 2,694,442 Swedish-born individuals were included in the study. Multimorbidity was defined by 45 NCDs. A principal component analysis (PCA) identified multimorbidity disease clusters. Odds ratios (OR) for VTE were calculated for the different multimorbidity disease clusters. There were 16% (n = 440,742) of multimorbid individuals in the study population. Forty-four of the individual 45 NCDs were associated with VTE. The PCA analysis identified nine multimorbidity disease clusters, F1-F9. Seven of these multimorbidity clusters were associated with VTE. The adjusted OR for VTE in the multimorbid patients was for the first three clusters: F1 (cardiometabolic diseases) 3.44 (95%CI 3.24-3.65), F2 (mental disorders) 2.25 (95%CI 2.14-2.37) and F3 (digestive system diseases) 4.35 (95%CI 3.63-5.22). There was an association between multimorbidity severity and OR for VTE. For instance, the occurrence of at least five diseases was in F1 and F2 associated with ORs for VTE: 8.17 (95%CI 6.32-10.55) and 6.31 (95%CI 4.34-9.17), respectively. In this nationwide study we have shown a strong association between VTE and different multimorbidity disease clusters that might be useful for VTE prediction.
摘要：
多浊度,即，两种或两种以上非传染性疾病，对社会来说是一个不断升级的挑战。静脉血栓栓塞症（VTE）是一种常见的心血管疾病，尚不清楚哪些多发病簇与VTE相关。我们的目的是检查多发病的不同常见病群与VTE之间的关联。该研究是一项扩展的（1997-2015年）瑞典横断面研究，使用国家患者登记册和多代登记册。共有2,694,442名瑞典出生的人被纳入研究。多浊度由45种NCDs定义。主成分分析(PCA)确定了多患病疾病集群。计算了不同多患病疾病集群的VTE的赔率比（OR）。研究人群中有16％（n=440,742）的多个体。45例NCDs个体中有44例与VTE相关。PCA分析确定了9个多患病疾病集群，F1-F9.这些多患病簇中的七个与VTE相关。多发病率患者中VTE的校正OR是前三组：F1（心脏代谢疾病）3.44（95CI3.24-3.65），F2（精神障碍）2.25（95CI2.14-2.37）和F3（消化系统疾病）4.35（95CI3.63-5.22）。多症严重程度与VTE的OR之间存在关联。例如,至少5种疾病的发生在F1和F2中与VTE的OR相关：8.17（95CI6.32-10.55）和6.31（95CI4.34-9.17），分别。在这项全国性的研究中，我们显示了VTE与不同多发病率疾病集群之间的强关联，这可能对VTE预测有用。
