Abstract：
Functional abdominal pain is a disorder in which central and peripheral sensitization processes converge, leading to hypersensitivity and allodynia. Differential diagnosis is made with organic digestive, renal, gynecological, endocrine, or neurological diseases. Treatment should be individualized for each patient. In cases of debilitating pain, therapy combining drugs with different mechanisms of action can be initiated, while in less severe cases, therapy with a progressive introduction of drugs based on clinical response is advised. The first line includes general lifestyle advice and antispasmodic substances, like peppermint oil, anticholinergic/antimuscarinic, and calcium channels antagonists. In the second line of treatment, neuromodulating agents are added. Finally, when these measures fail, third-line treatments such as gabapentine and atypical antipsychotics are considered. Psychological interventions should be considered if specialized therapists are available to manage these disorders.
摘要：
功能性腹痛是一种中枢和外周致敏过程融合的疾病，导致超敏反应和异常性疼痛。鉴别诊断是用有机消化，肾,妇科,内分泌，或神经系统疾病。每个患者的治疗应该是个性化的。在使人衰弱的疼痛的情况下，可以启动具有不同作用机制的药物组合疗法，而在不太严重的情况下，建议根据临床反应逐步引入药物进行治疗.第一行包括一般生活方式建议和抗痉挛物质，像薄荷油,抗胆碱能/抗毒蕈碱，和钙通道拮抗剂.在二线治疗中，添加神经调节剂。最后,当这些措施失败时，三线治疗如加巴喷丁和非典型抗精神病药被考虑.如果有专门的治疗师可以治疗这些疾病，则应考虑进行心理干预。
