Abstract：
BACKGROUND: Progressive Supranuclear Palsy (PSP) is a sporadic neurodegenerative disease without a clear geographic prevalence. Cohorts studied in the UK and India showed no higher prevalence of atypical parkinsonism in South Asian patients. We describe the ethnic and racial background of PSP patients in the Greater Toronto Area (GTA), Canada.
METHODS: A prospective observational study of patients with clinically probable PSP evaluated at the dedicated Rossy PSP program. Demographic and clinical data were collected at baseline including PSP phenotype. Results were compared with the latest demographic information from the greater Toronto area.
RESULTS: Of the 197 patients screened, 135 had probable PSP and resided within the GTA. The mean age at visit was 71.1 years, disease duration 4.4 years, and disease severity moderate. Compared to our catchment area, there was a higher proportion of patients with a South Asian origin and a lower proportion of patients from East and Southeastern Asia and Africa. A secondary analysis using population census data limited to individuals greater than 65 confirmed the significantly higher representation of South Asians in our clinic but found no differences for other racial and ethnic origins.
CONCLUSIONS: Evaluation of this Toronto cohort found a greater than expected proportion of affected individuals with South Asian ethnic and racial origin. Despite limitations, our results suggest the possibility of a racial and ethnic predisposition to PSP. Further studies are needed to confirm and to address potential associated risk factors, and genome-environmental interactions.
METHODS: A prospective observational study of patients with clinically probable PSP evaluated at the dedicated Rossy PSP program. Demographic and clinical data were collected at baseline including PSP phenotype. Results were compared with the latest demographic information from the greater Toronto area.
RESULTS: Of the 197 patients screened, 135 had probable PSP and resided within the GTA. The mean age at visit was 71.1 years, disease duration 4.4 years, and disease severity moderate. Compared to our catchment area, there was a higher proportion of patients with a South Asian origin and a lower proportion of patients from East and Southeastern Asia and Africa. A secondary analysis using population census data limited to individuals greater than 65 confirmed the significantly higher representation of South Asians in our clinic but found no differences for other racial and ethnic origins.
CONCLUSIONS: Evaluation of this Toronto cohort found a greater than expected proportion of affected individuals with South Asian ethnic and racial origin. Despite limitations, our results suggest the possibility of a racial and ethnic predisposition to PSP. Further studies are needed to confirm and to address potential associated risk factors, and genome-environmental interactions.
摘要：
背景：进行性核上性麻痹（PSP）是一种散发的神经退行性疾病，没有明确的地理患病率。在英国和印度研究的队列显示，南亚患者中非典型帕金森病的患病率不高。我们描述了大多伦多地区（GTA）PSP患者的种族和种族背景，加拿大。
方法：一项前瞻性观察性研究，在专用RossyPSP项目中对临床可能的PSP患者进行评估。在基线时收集人口统计学和临床数据,包括PSP表型。将结果与大多伦多地区的最新人口统计信息进行了比较。
结果：在筛选的197名患者中，135具有可能的PSP并居住在GTA内。就诊时的平均年龄为71.1岁,疾病持续时间4.4年，和疾病严重程度中等。与我们的集水区相比，来自南亚的患者比例较高,来自东亚、东南亚和非洲的患者比例较低.使用人口普查数据进行的二次分析仅限于65岁以上的个人，证实了我们诊所中南亚人的比例明显更高，但发现其他种族和族裔没有差异。
结论：对多伦多队列的评估发现，具有南亚民族和种族血统的受影响个体的比例高于预期。尽管有局限性,我们的结果表明PSP可能存在种族和民族倾向.需要进一步的研究来确认和解决潜在的相关风险因素。和基因组-环境相互作用。
方法：一项前瞻性观察性研究，在专用RossyPSP项目中对临床可能的PSP患者进行评估。在基线时收集人口统计学和临床数据,包括PSP表型。将结果与大多伦多地区的最新人口统计信息进行了比较。
结果：在筛选的197名患者中，135具有可能的PSP并居住在GTA内。就诊时的平均年龄为71.1岁,疾病持续时间4.4年，和疾病严重程度中等。与我们的集水区相比，来自南亚的患者比例较高,来自东亚、东南亚和非洲的患者比例较低.使用人口普查数据进行的二次分析仅限于65岁以上的个人，证实了我们诊所中南亚人的比例明显更高，但发现其他种族和族裔没有差异。
结论：对多伦多队列的评估发现，具有南亚民族和种族血统的受影响个体的比例高于预期。尽管有局限性,我们的结果表明PSP可能存在种族和民族倾向.需要进一步的研究来确认和解决潜在的相关风险因素。和基因组-环境相互作用。
