Abstract：
Transdermal drug delivery systems (TDDS) have received significant attention in recent years. TDDS are flexible systems that transport active components to the skin for either localized or systemic delivery of drugs through the skin. Among the three main layers of skin, the outermost layer, called the stratum corneum (SC), prevents the entry of water-loving bacteria and drugs with a high molecular weight. The challenge lies in successfully delivering drugs through the skin, which crosses the stratum corneum. The popularity of lipid-based vesicular delivery systems has increased in recent years due to their ability to deliver both hydrophilic and hydrophobic drugs. Ethosomes are specialized vesicles made of phospholipids that can store large amounts of ethanol. Ethosome structure and substance promote skin permeability and bioavailability. This article covers ethosome compositions, types, medication delivery techniques, stability, and safety. In addition to this, an in-depth analysis of the employment of ethosomes in drug delivery applications for a wide range of diseases has also been discussed. This review article highlights different aspects of ethosomes, such as their synthesis, characterization, marketed formulation, recent advancements in TDDS, and applications.
摘要：
近年来，经皮给药系统（TDDS）受到了广泛的关注。TDDS是将活性组分运输到皮肤以通过皮肤局部或全身递送药物的柔性系统。在三个主要的皮肤层中，最外层,称为角质层（SC），防止嗜水细菌和高分子量药物的进入。挑战在于成功地通过皮肤输送药物，穿过角质层。近年来,基于脂质的囊泡递送系统的普及由于其递送亲水性和疏水性药物的能力而增加。醇质体是由磷脂制成的专门囊泡，可以储存大量的乙醇。乙醇体结构和物质促进皮肤渗透性和生物利用度。这篇文章涵盖了乙醇体成分，类型,药物输送技术，稳定性,和安全。除此之外,还讨论了醇质体在广泛疾病的药物递送应用中的应用的深入分析。这篇综述文章强调了乙醇体的不同方面，比如他们的合成，表征，上市配方，TDDS的最新进展，和应用。
