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Abstract：
The prevalence of diseases characterised by eosinophilia is on the rise, emphasising the importance of understanding the role of eosinophils in these conditions. Eosinophils are a subset of granulocytes that contribute to the body\'s defence against bacterial, viral, and parasitic infections, but they are also implicated in haemostatic processes, including immunoregulation and allergic reactions. They contain cytoplasmic granules which can be selectively mobilised and secrete specific proteins, including chemokines, cytokines, enzymes, extracellular matrix, and growth factors. There are multiple biological and emerging functions of these specialised immune cells, including cancer surveillance, tissue remodelling and development. Several oral diseases, including oral cancer, are associated with either tissue or blood eosinophilia; however, their exact mechanism of action in the pathogenesis of these diseases remains unclear. This review presents a comprehensive synopsis of the most recent literature for both clinicians and scientists in relation to eosinophils and oral diseases and reveals a significant knowledge gap in this area of research.
摘要：
以嗜酸性粒细胞增多为特征的疾病的患病率正在上升，强调了解嗜酸性粒细胞在这些疾病中的作用的重要性。嗜酸性粒细胞是粒细胞的一个子集，有助于身体防御细菌，病毒，和寄生虫感染，但它们也与止血过程有关，包括免疫调节和过敏反应。它们含有细胞质颗粒，可以选择性动员并分泌特定的蛋白质，包括趋化因子,细胞因子,酶，细胞外基质，和增长因素。这些专门的免疫细胞有多种生物学和新兴功能，包括癌症监测,组织重塑和发育。几种口腔疾病，包括口腔癌,与组织或血液嗜酸性粒细胞增多有关；然而，它们在这些疾病发病机制中的确切作用机制尚不清楚。这篇综述为临床医生和科学家提供了与嗜酸性粒细胞和口腔疾病有关的最新文献的全面概述，并揭示了该研究领域的重大知识差距。
