PDF(Pubmed)
Abstract：
Dental tissue stem cells (DTSCs) are well known for their multipotent capacity and regenerative potential. They also play an important role in the immune response of inflammatory processes derived from caries lesions, periodontitis, and gingivitis. These oral diseases are triggered by toxins known as lipopolysaccharides (LPS) produced by gram-negative bacteria. LPS present molecular patterns associated with pathogens and are recognized by Toll-like receptors (TLRs) in dental stem cells. In this review, we describe the effect of LPS on the biological behavior of DTSCs. We also focus on the molecular sensors, signaling pathways, and emerging players participating in the interaction of DTSCs with lipopolysaccharides. Although the scientific advances generated provide an understanding of the immunomodulatory potential of DTSCs, there are still new reflections to explore with regard to their clinical application in the treatment of oral inflammatory diseases.
摘要：
牙科组织干细胞（DTSC）以其多能能力和再生潜力而闻名。它们在龋齿病变引起的炎症过程的免疫反应中也起着重要作用，牙周炎,和牙龈炎.这些口腔疾病是由革兰氏阴性细菌产生的称为脂多糖(LPS)的毒素引发的。LPS呈现与病原体相关的分子模式，并被牙齿干细胞中的Toll样受体（TLR）识别。在这次审查中,我们描述了LPS对DTSCs生物学行为的影响。我们还关注分子传感器，信号通路，以及参与DTSCs与脂多糖相互作用的新兴参与者。尽管产生的科学进步提供了对DTSCs免疫调节潜力的理解，关于其在口腔炎症性疾病治疗中的临床应用仍有新的思考。
