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Abstract：
This study compared the overall postoperative recovery of patients who underwent total intravenous anesthesia with remimazolam or propofol, using the Quality of Recovery-15 questionnaire (QoR-15). Seventy-two patients who underwent spine surgery with intraoperative neurophysiological monitoring (IONM) were randomly categorized into the remimazolam group (group R) or propofol group (group P). On the first postoperative day, the QoR-15 scores for groups P and R were 114 and 112, respectively, indicating no significant difference (p = 0.691). Similarly, group-time interaction effects on QoR-15 scores were not significantly different. In the post-anesthesia care unit, the pain intensity at rest was notably higher in group P than in group R (3.0 [0.0] vs. 2.8 [0.5], respectively, p = 0.009). Although the intraoperative consumption of remifentanil was higher in group R (1452.4 µg vs. 2066.8 µg, respectively, p < 0.001), the intraoperative use of vasopressors was lower in group R (1705.6 µg vs. 286.1 µg, respectively, p < 0.001) compared to group P. Group R exhibited significantly lower variability in mean blood pressure over time compared to group P. Remimazolam was viewed as a promising intravenous agent for general anesthesia, showing potential to replace propofol in spine surgery with IONM, considering both recovery quality and intraoperative hemodynamic stability.
摘要：
这项研究比较了使用雷米唑仑或丙泊酚进行全静脉麻醉的患者的总体术后恢复情况，使用恢复质量-15问卷(QoR-15)。72例接受术中神经生理监测（IONM）脊柱手术的患者被随机分为雷米唑仑组（R组）或丙泊酚组（P组）。术后第一天,P组和R组的QoR-15得分分别为114和112，表明无显著差异(p=0.691)。同样，组-时间交互作用对QoR-15评分无显著差异.在麻醉后护理室，P组静息时的疼痛强度明显高于R组（3.0[0.0]vs.2.8[0.5],分别,p=0.009)。尽管R组术中瑞芬太尼的消耗量较高（1452.4µgvs.2066.8微克，分别,p<0.001)，R组的术中血管加压药的使用较低（1705.6µgvs.286.1µg,分别,p<0.001）与P组相比，R组的平均血压随时间的变异性显着低于P组。显示出在脊柱手术中用IONM替代异丙酚的潜力，同时考虑恢复质量和术中血流动力学稳定性。
