PDF(Pubmed)
Abstract：
Tumor angiogenesis, the formation of new blood vessels within the tumor microenvironment, is considered a hallmark of cancer progression and represents a crucial target for therapeutic intervention. The tumor microenvironment is characterized by a complex interplay between proangiogenic and antiangiogenic factors, regulating the vascularization necessary for tumor growth and metastasis. The study of angiogenesis involves a spectrum of techniques, spanning from biomarker assessment to advanced imaging modalities. This comprehensive review aims to provide insights into the molecular intricacies, regulatory dynamics, and clinical implications of tumor angiogenesis. By delving into these aspects, we gain a deeper understanding of the processes driving vascularization in tumors, paving the way for the development of novel and effective antiangiogenic therapies in the fight against cancer.
摘要：
肿瘤血管生成,肿瘤微环境内新血管的形成，被认为是癌症进展的标志，代表了治疗干预的关键目标。肿瘤微环境的特征在于促血管生成因子和抗血管生成因子之间的复杂相互作用。调节肿瘤生长和转移所必需的血管形成。血管生成的研究涉及一系列技术，从生物标志物评估到先进的成像模式。这篇全面的综述旨在提供对分子复杂性的见解，监管动态，和肿瘤血管生成的临床意义。通过深入研究这些方面，我们对肿瘤血管化的驱动过程有了更深入的了解，为在对抗癌症中开发新的和有效的抗血管生成疗法铺平了道路。
