Abstract：
Recent research has highlighted an important role for the molecular circadian machinery in the regulation of tissue-specific function and stress responses. Indeed, disruption of circadian function, which is pervasive in modern society, is linked to accelerated aging, obesity, and type 2 diabetes. Furthermore, evidence supporting the importance of the circadian clock within both the mature muscle tissue and satellite cells to regulate the maintenance of muscle mass and repair capacity in response injury has recently emerged. Here, we review the discovery of circadian clocks within the satellite cell (a.k.a. adult muscle stem cell) and how they act to regulate metabolism, epigenetics, and myogenesis during both healthy and diseased states.
摘要：
最近的研究强调了分子昼夜节律机制在调节组织特异性功能和应激反应中的重要作用。的确,昼夜节律功能的中断，这在现代社会普遍存在，与加速衰老有关，肥胖，和2型糖尿病。此外，最近有证据表明，成熟肌肉组织和卫星细胞内的生物钟对调节肌肉质量的维持和响应损伤的修复能力的重要性。这里,我们回顾了卫星细胞（也称为成年肌肉干细胞）中昼夜节律时钟的发现，以及它们如何调节新陈代谢，表观遗传学,和健康和疾病状态下的肌生成。
