Abstract：
The role of the cellular microenvironment has recently gained attention in the context of muscle health, adaption, and disease. Emerging evidence supports major roles for the extracellular matrix (ECM) in regeneration and the dynamic regulation of the satellite cell niche. Satellite cells normally reside in a quiescent state in healthy muscle, but upon muscle injury, they activate, proliferate, and fuse to the damaged fibers to restore muscle function and architecture. This chapter reviews the composition and mechanical properties of skeletal muscle ECM and the role of these factors in contributing to the satellite cell niche that impact muscle regeneration. In addition, the chapter details the effects of satellite cell-matrix interactions and provides evidence that there is bidirectional regulation affecting both the cellular and extracellular microenvironment within skeletal muscle. Lastly, emerging methods to investigate satellite cell-matrix interactions will be presented.
摘要：
细胞微环境的作用最近在肌肉健康的背景下得到了关注，适应,和疾病。新的证据支持细胞外基质（ECM）在再生和卫星细胞生态位的动态调节中的主要作用。卫星细胞通常在健康肌肉中处于静止状态，但是肌肉损伤时,他们激活，增殖，融合受损的纤维以恢复肌肉功能和结构。本章回顾了骨骼肌ECM的组成和机械性能，以及这些因素在影响肌肉再生的卫星细胞生态位的作用。此外,本章详细介绍了卫星细胞-基质相互作用的影响,并提供了影响骨骼肌内细胞和细胞外微环境的双向调节的证据.最后,将提出研究卫星细胞-基质相互作用的新兴方法。
