Abstract：
The objective of this study was to determine whether a novel footbath solution containing stannous fluoride (SnF2) was superior to 5% copper sulfate solution for the treatment and prevention of digital dermatitis (DD) in dairy cattle. Study 1 was conducted over 4 weeks in Missouri and involved 34 lactating Holstein-Friesian cows with hind feet DD lesions. Cows in group SF walked through a footbath containing a proprietary formulation of SnF2 once weekly, whereas cows in group CS walked through a 5% CuSO4 footbath once daily for 5 d each week. Study 2 was conducted over 8 weeks in California and involved 40 lactating Holstein-Friesian cows with hind feet DD lesions. Cows in group SF walked through a SnF2 footbath for 3 consecutive days then once a week for the following 7 weeks. Cows in group CS walked through a 5% CuSO4 footbath 3 times each week for 8 weeks. Data collection included lesion type, lesion area, locomotion score, and pain score. Digital dermatitis was actively transmitted in study 1, and lesion area and locomotion scores were lower in group SF than group CS. In contrast, DD was not actively transmitted in study 2, and lesion area and locomotion scores were similar in groups SF and CS. Stannous fluoride delayed the development of active DD lesions in study 1 compared with copper sulfate, with a lower relative risk (0.57, P < 0.001) of a hind foot developing an active DD lesion over 28 d. However, SnF2 decreased the rate that active DD lesions transitioned to M3, M4, or M0 lesions compared with 5% copper sulfate in both studies, with the relative risk of a hind foot with an active DD lesion transitioning to M3, M4, or M0 in group SF being slightly lower in study 1 (0.83, P = 0.042) and study 2 (0.90, P = 0.020) than group CS. Our findings demonstrated that walking cows through a stannous fluoride footbath once per week in a herd undergoing active transmission of infection was more effective in preventing active DD lesions, but less effective in treating active DD lesions, than walking cows through a copper sulfate footbath 4 times per week. The novel SnF2 footbath solution shows promise for controlling DD in dairy herds that want an alternative footbath solution to CuSO4 and are interested in limiting the environmental accumulation of copper.
摘要：
这项研究的目的是确定含有氟化亚锡（SnF2）的新型足浴溶液是否优于5％硫酸铜溶液，以治疗和预防奶牛的指性皮炎（DD）。研究1在密苏里州进行了4周，涉及34头泌乳后足DD病变的荷斯坦-弗里斯奶牛。SF组中的奶牛每周一次经过含有专有SnF2配方的足浴，而CS组的奶牛每天一次经过5％的CuSO4足浴，每周5d。研究2在加利福尼亚州进行了8周，涉及40头泌乳荷斯坦-弗里斯奶牛，后足DD病变。SF组中的奶牛连续3天通过SnF2足浴，然后在接下来的7周内每周一次。CS组奶牛每周3次通过5%CuSO4足浴，共8周。数据收集包括病变类型，病变面积,运动评分,和疼痛评分。在研究1中，手指性皮炎积极传播，SF组的病变面积和运动评分低于CS组。相比之下,研究2中DD没有主动传播，SF组和CS组的病变面积和运动评分相似。与硫酸铜相比，研究1中的氟化亚锡延迟了活性DD病变的发展，后足在28d内发展为活动性DD病变的相对风险较低（0.57，P<0.001）。但是，在两项研究中，与5%硫酸铜相比，SnF2降低了活动性DD病变过渡到M3、M4或M0病变的比率。在研究1（0.83，P=0.042）和研究2（0.90，P=0.020）中，SF组中活动性DD病变过渡到M3，M4或M0的后足的相对风险略低于CS组。我们的发现表明，在经历感染主动传播的牛群中，每周一次步行通过氟化亚锡足浴可以更有效地预防活动性DD病变，但在治疗活动性DD病变方面效果较差，比每周4次让奶牛通过硫酸铜足浴。新型SnF2足浴溶液有望控制想要替代CuSO4的足浴溶液的乳牛群的DD，并对限制铜的环境积累感兴趣。
