Abstract：
UNASSIGNED: Sleep is a potentially modifiable factor associated with dementia, including Alzheimer\'s disease, but current evidence supporting this is insufficient.
UNASSIGNED: This study aimed to determine whether sleep duration and bedtime patterns are associated with the risk of dementia among middle-aged and older people.
UNASSIGNED: This cohort study had an eight-year follow-up period. Participants were 13,601 community-dwelling people aged 40-74 years living in Murakami (Niigata, Japan). Data were collected using a self-administered questionnaire. Predictors were self-reported sleep duration and bedtime, and the outcome was newly-diagnosed dementia determined using the long-term care insurance database. Covariates were demographic characteristics, body mass index, smoking, alcohol consumption, total physical activity, insomnia symptoms, disease history, and either bedtime or sleep duration. Cox proportional hazard models were used to calculate hazard ratios (HRs).
UNASSIGNED: The mean age of participants at baseline was 59.2 years. Over a mean follow-up period of 8.0 years, 319 cases of dementia were observed. A long self-reported sleep duration relative to the reference sleep duration (7 hours) was associated with increased dementia risk, with the \"8 hours\" group (adjusted HR = 1.30, 95% CI:0.99-1.73) and \"≥9 hours\" group (adjusted HR = 1.46, 95% CI:1.00-2.15) having an increased risk (marginally significant) relative to the reference group. Early bedtime was associated with increased dementia risk (adjusted p for trend = 0.0010), with the \"21 : 00 or earlier\" group (adjusted HR = 1.61, 95% CI:1.14-2.28) having an increased risk relative to the reference (\"23 : 00\").
UNASSIGNED: A long self-reported sleep duration and early bedtime are both associated with increased dementia risk in middle-aged and older people.
UNASSIGNED: This study aimed to determine whether sleep duration and bedtime patterns are associated with the risk of dementia among middle-aged and older people.
UNASSIGNED: This cohort study had an eight-year follow-up period. Participants were 13,601 community-dwelling people aged 40-74 years living in Murakami (Niigata, Japan). Data were collected using a self-administered questionnaire. Predictors were self-reported sleep duration and bedtime, and the outcome was newly-diagnosed dementia determined using the long-term care insurance database. Covariates were demographic characteristics, body mass index, smoking, alcohol consumption, total physical activity, insomnia symptoms, disease history, and either bedtime or sleep duration. Cox proportional hazard models were used to calculate hazard ratios (HRs).
UNASSIGNED: The mean age of participants at baseline was 59.2 years. Over a mean follow-up period of 8.0 years, 319 cases of dementia were observed. A long self-reported sleep duration relative to the reference sleep duration (7 hours) was associated with increased dementia risk, with the \"8 hours\" group (adjusted HR = 1.30, 95% CI:0.99-1.73) and \"≥9 hours\" group (adjusted HR = 1.46, 95% CI:1.00-2.15) having an increased risk (marginally significant) relative to the reference group. Early bedtime was associated with increased dementia risk (adjusted p for trend = 0.0010), with the \"21 : 00 or earlier\" group (adjusted HR = 1.61, 95% CI:1.14-2.28) having an increased risk relative to the reference (\"23 : 00\").
UNASSIGNED: A long self-reported sleep duration and early bedtime are both associated with increased dementia risk in middle-aged and older people.
摘要：
■睡眠是与痴呆症相关的潜在可改变因素，包括老年痴呆症,但是目前支持这一点的证据是不够的。
■这项研究旨在确定睡眠时间和就寝时间模式是否与中老年人患痴呆症的风险有关。
■这项队列研究有8年的随访期。参与者是居住在村上的13,601名40-74岁的社区居民（新泻，日本）。使用自我管理问卷收集数据。预测因素是自我报告的睡眠时间和就寝时间，结局是使用长期护理保险数据库确定的新诊断痴呆症.协变量是人口统计学特征，身体质量指数,吸烟,酒精消费,总的身体活动，失眠症状,病史,睡前或睡眠时间。Cox比例风险模型用于计算风险比(HR)。
■基线时参与者的平均年龄为59.2岁。在8.0年的平均随访期内，观察到319例痴呆。相对于参考睡眠持续时间（7小时），自我报告的睡眠持续时间较长与痴呆风险增加有关。与参照组相比,“8小时”组(校正后HR=1.30,95%CI:0.99-1.73)和“≥9小时”组(校正后HR=1.46,95%CI:1.00-2.15)的风险增加(略显着).早期就寝时间与痴呆风险增加相关（趋势调整后p=0.0010），“21:00或更早”组(调整后的HR=1.61，95%CI:1.14-2.28)相对于参考(“23:00”)风险增加。
■自我报告的睡眠时间长和早睡时间都与中老年人痴呆风险增加有关。
■这项研究旨在确定睡眠时间和就寝时间模式是否与中老年人患痴呆症的风险有关。
■这项队列研究有8年的随访期。参与者是居住在村上的13,601名40-74岁的社区居民（新泻，日本）。使用自我管理问卷收集数据。预测因素是自我报告的睡眠时间和就寝时间，结局是使用长期护理保险数据库确定的新诊断痴呆症.协变量是人口统计学特征，身体质量指数,吸烟,酒精消费,总的身体活动，失眠症状,病史,睡前或睡眠时间。Cox比例风险模型用于计算风险比(HR)。
■基线时参与者的平均年龄为59.2岁。在8.0年的平均随访期内，观察到319例痴呆。相对于参考睡眠持续时间（7小时），自我报告的睡眠持续时间较长与痴呆风险增加有关。与参照组相比,“8小时”组(校正后HR=1.30,95%CI:0.99-1.73)和“≥9小时”组(校正后HR=1.46,95%CI:1.00-2.15)的风险增加(略显着).早期就寝时间与痴呆风险增加相关（趋势调整后p=0.0010），“21:00或更早”组(调整后的HR=1.61，95%CI:1.14-2.28)相对于参考(“23:00”)风险增加。
■自我报告的睡眠时间长和早睡时间都与中老年人痴呆风险增加有关。
