PDF(Pubmed)
Abstract：
2-Phenoxyethanol (PhE) is an aromatic glycol ether and is used in a variety of functions and applications, e.g., as preservative in pharmaceuticals, cosmetic and personal care products, as biocide in disinfectants (e.g. human hygiene), or as a solvent in formulations (e.g. coatings, functional fluids). Despite its widespread use, little is yet known on its biotransformation and toxicokinetics in humans. Therefore, a pilot study was conducted with oral administration of PhE (5 mg/kg body weight) to five volunteers. Blood and urine samples were collected and analyzed for PhE and three of its presumed metabolites up to 48 h post-exposure. Additionally, one volunteer was dermally exposed to PhE and monitored until 72 h post-exposure. PhE was rapidly resorbed following both oral and dermal application with tmax-levels in blood of about 1 h and 3 h, respectively. Metabolism of PhE was observed to be rather extensive with phenoxyacetic acid (PhAA) and 4-hydroxyphenoxyacetic acid (4-OH-PhAA) as the main metabolites found in blood and urine following oral and dermal exposure. PhE was excreted rapidly and efficiently via urine mostly in metabolized form: following oral exposure, on average 77% and 12% of the applied dose was excreted within 48 h as PhAA and 4-OH-PhAA, respectively. A similar metabolism pattern was observed following the single dermal exposure experiment. The obtained data on biotransformation and toxicokinetics of PhE in humans provide valuable information on this important chemical and will be highly useful for pharmacokinetic modelling and evaluation of human PhE exposure.
摘要：
2-苯氧乙醇（PhE）是一种芳香族二醇醚，用于多种功能和应用，例如，作为药物中的防腐剂，化妆品和个人护理产品，作为消毒剂中的杀菌剂(例如人类卫生)，或作为配方中的溶剂(例如涂料，功能流体)。尽管它广泛使用，对其在人类中的生物转化和毒物动力学知之甚少。因此,对5名志愿者口服PhE(5mg/kg体重)进行了一项初步研究.收集血液和尿液样品，并在暴露后48小时内分析PhE及其三种假定的代谢物。此外,一名志愿者在皮肤上暴露于PhE，并在暴露后72小时进行监测。口服和皮肤施用后，PhE迅速吸收，血液中的tmax水平约为1小时和3小时，分别。观察到PhE的代谢相当广泛，苯氧乙酸（PhAA）和4-羟基苯氧乙酸（4-OH-PhAA）是口服和皮肤暴露后血液和尿液中发现的主要代谢产物。PhE主要以代谢形式通过尿液快速有效地排泄：口服暴露后，平均77%和12%的应用剂量在48小时内排泄为PhAA和4-OH-PhAA，分别。在单次皮肤暴露实验后观察到类似的代谢模式。获得的有关PhE在人类中的生物转化和毒物动力学的数据提供了有关这种重要化学物质的有价值的信息，对于药代动力学建模和评估人类PhE暴露非常有用。
