METHODS: We measured the global, regional and national morbidity, mortality and DALYs of CE from 1990 to 2019 based on the Global Burden of Disease Study 2019 (GBD 2019) data, and we examined the correlation between socioeconomic development levels and the disease burden of CE. In addition, the disease burden due to CE was projected from 2020 to 2030.
RESULTS: The age-standardized incidence rate (ASIR) of CE reduced from 2.65/105 [95% UI: (1.87/105 to 3.7/105)] in 1990 to 2.6/105 [95% UI: (1.72/105 to 3.79/105)] in 2019 (EAPC = -0.18%). The number of deaths, DALYs, age-standardized mortality rate (ASMR) and age-standardized DALY rate due to CE all showed a tendency to decline from 1990 to 2019. A higher disease burden of CE was measured in women than in men in 2019. There was a significant difference in the ASMR of CE by region according to the socio-demographic index (SDI), and lower burdens of CE were estimated in high-SDI regions. The global ASIR of CE is projected to decline from 2020 to 2030; however, the ASMR and age-standardized DALY rate are projected to rise.
CONCLUSIONS: The global burden of CE remains high, and it is recommended that more health resources are allocated to low-SDI regions, women and the elderly aged 55 to 65 years to reduce the disease burden of CE.
方法:我们测量了全球,区域和国家发病率,根据2019年全球疾病负担研究(GBD2019)数据,1990年至2019年的CE死亡率和DALYs,我们研究了社会经济发展水平与CE疾病负担之间的相关性。此外,CE造成的疾病负担预计从2020年到2030年。
结果:CE的年龄标准化发病率(ASIR)从1990年的2.65/105[95%UI:(1.87/105至3.7/105)]降低到2019年的2.6/105[95%UI:(1.72/105至3.79/105)](EAPC=-0.18%)。死亡人数,DALYs,从1990年到2019年,CE导致的年龄标准化死亡率(ASMR)和年龄标准化DALY率均呈下降趋势。2019年,女性的CE疾病负担高于男性。根据社会人口统计学指数(SDI),各地区的CEASMR存在显着差异,在高SDI地区,估计CE负担较低。从2020年到2030年,CE的全球ASIR预计将下降;然而,ASMR和年龄标准化的DALY率预计将上升。
结论:全球CE负担仍然很高,建议将更多的卫生资源分配给低SDI地区,55~65岁的女性和老年人减少CE的疾病负担。