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Abstract：
Cutaneous leishmaniasis (CL), caused by Leishmania braziliensis, in recent decades has shown decreasing cure rates after treatment with meglumine antimoniate (MA). Granulocyte colony-stimulating factor (G-CSF) is a cytokine associated with epithelialization and healing processes.
METHODS: This study compares the effectiveness of G-CSF associated with MA in the treatment of CL. A total of 32 patients aged between 18 and 50 years with CL confirmed for L. braziliensis were included in this study. G-CSF or placebo (0.9% saline) was applied by intralesional infiltration at four equidistant points on the edges of the largest ulcer on days 0 and 15 of treatment associated with intravenous MA.
RESULTS: Males predominated in the G-CSF group (59%), while females predominated in the control group (53%). Injuries to the lower limbs predominated in both study groups. The cure rate in the G-CSF group was 65% and in the control group it was 47%, 90 days after initiation of therapy.
CONCLUSIONS: Our data indicate that the association of G-CSF with MA is not superior to MA monotherapy. Although not significant, the potential benefit of this combination deserves further investigation. The use of higher doses or other routes of application of G-CSF in a greater number of patients should contribute to a definitive response.
METHODS: This study compares the effectiveness of G-CSF associated with MA in the treatment of CL. A total of 32 patients aged between 18 and 50 years with CL confirmed for L. braziliensis were included in this study. G-CSF or placebo (0.9% saline) was applied by intralesional infiltration at four equidistant points on the edges of the largest ulcer on days 0 and 15 of treatment associated with intravenous MA.
RESULTS: Males predominated in the G-CSF group (59%), while females predominated in the control group (53%). Injuries to the lower limbs predominated in both study groups. The cure rate in the G-CSF group was 65% and in the control group it was 47%, 90 days after initiation of therapy.
CONCLUSIONS: Our data indicate that the association of G-CSF with MA is not superior to MA monotherapy. Although not significant, the potential benefit of this combination deserves further investigation. The use of higher doses or other routes of application of G-CSF in a greater number of patients should contribute to a definitive response.
摘要：
皮肤利什曼病（CL），由巴西利什曼原虫引起，近几十年来，使用抗蒙酸葡甲胺（MA）治疗后，治愈率下降。粒细胞集落刺激因子(G-CSF)是与上皮形成和愈合过程相关的细胞因子。
方法：本研究比较了与MA相关的G-CSF治疗CL的有效性。本研究共纳入32例年龄在18至50岁之间的CL患者。在与静脉内MA相关的治疗的第0天和第15天，通过在最大溃疡边缘的四个等距点处进行病灶内浸润来施加G-CSF或安慰剂（0.9％盐水）。
结果：男性在G-CSF组中占主导地位（59％），而女性在对照组中占主导地位（53％）。在两个研究组中，下肢损伤占主导地位。G-CSF组治愈率为65％，对照组为47％，治疗开始后90天。
结论：我们的数据表明G-CSF与MA的相关性并不优于MA单一疗法。虽然不重要，这种组合的潜在益处值得进一步研究.在更多患者中使用更高剂量或其他施用G-CSF的途径应有助于确定的反应。
方法：本研究比较了与MA相关的G-CSF治疗CL的有效性。本研究共纳入32例年龄在18至50岁之间的CL患者。在与静脉内MA相关的治疗的第0天和第15天，通过在最大溃疡边缘的四个等距点处进行病灶内浸润来施加G-CSF或安慰剂（0.9％盐水）。
结果：男性在G-CSF组中占主导地位（59％），而女性在对照组中占主导地位（53％）。在两个研究组中，下肢损伤占主导地位。G-CSF组治愈率为65％，对照组为47％，治疗开始后90天。
结论：我们的数据表明G-CSF与MA的相关性并不优于MA单一疗法。虽然不重要，这种组合的潜在益处值得进一步研究.在更多患者中使用更高剂量或其他施用G-CSF的途径应有助于确定的反应。
