PDF(Pubmed)
Abstract：
Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, and structural similarity to the extracellular matrix. Recent chemical advancements have bolstered their versatility, facilitating the integration of the molecules guiding cellular activities and enabling their controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity and network imperfections, which adversely affect their mechanical properties, diffusion rates, and biological activity. In response to these challenges, hybrid hydrogels have emerged, aiming to enhance their strength, drug release efficiency, and therapeutic effectiveness. These hybrid hydrogels, featuring improved formulations, are tailored for controlled drug release and tissue regeneration across both soft and hard tissues. The scientific community has increasingly recognized the versatile characteristics of hybrid hydrogels, particularly in the biomedical sector. This comprehensive review delves into recent advancements in hybrid hydrogel systems, covering the diverse types, modification strategies, and the integration of nano/microstructures. The discussion includes innovative fabrication techniques such as click reactions, 3D printing, and photopatterning alongside the elucidation of the release mechanisms of bioactive molecules. By addressing challenges, the review underscores diverse biomedical applications and envisages a promising future for hybrid hydrogels across various domains in the biomedical field.
摘要：
水凝胶,是能够吸收和保留水性流体的亲水性聚合物网络，由于其高含水量，在生物医学应用中具有重要的前景，渗透性,和结构相似的细胞外基质。最近的化学进步增强了它们的多功能性，促进指导细胞活动的分子的整合，并使它们在时间限制下的受控激活成为可能。然而,传统的合成水凝胶具有固有的弱点，如异质性和网络缺陷，对它们的机械性能产生不利影响，扩散速率,和生物活性。为了应对这些挑战,混合水凝胶已经出现，旨在增强他们的力量，药物释放效率，和治疗效果。这些混合水凝胶，具有改进的配方，是专为控制药物释放和组织再生在软组织和硬组织。科学界越来越认识到混合水凝胶的多功能特性，特别是在生物医学领域。这篇全面的综述深入研究了混合水凝胶系统的最新进展，涵盖了各种类型，修改策略，和纳米/微结构的集成。讨论包括创新的制造技术，如点击反应，3D打印,和光图案化以及生物活性分子释放机制的阐明。通过应对挑战，这篇综述强调了不同的生物医学应用，并展望了生物医学领域各个领域的混合水凝胶的前景。
