PDF(Pubmed)
Abstract：
Despite breakthroughs in modern medical care, the incidence of cardiovascular disease (CVD) is even more prevalent globally. Increasing epidemiologic evidence indicates that emerging cardiovascular risk factors arising from the modern lifestyle, including psychosocial stress, sleep problems, unhealthy diet patterns, physical inactivity/sedentary behavior, alcohol consumption, and tobacco smoking, contribute significantly to this worldwide epidemic, while its underpinning mechanisms are enigmatic. Hematological and immune systems were recently demonstrated to play integrative roles in linking lifestyle to cardiovascular health. In particular, alterations in hematopoietic stem cell (HSC) homeostasis, which is usually characterized by proliferation, expansion, mobilization, megakaryocyte/myeloid-biased differentiation, and/or the pro-inflammatory priming of HSCs, have been shown to be involved in the persistent overproduction of pro-inflammatory myeloid leukocytes and platelets, the cellular protagonists of cardiovascular inflammation and thrombosis, respectively. Furthermore, certain lifestyle factors, such as a healthy diet pattern and physical exercise, have been documented to exert cardiovascular protective effects through promoting quiescence, bone marrow retention, balanced differentiation, and/or the anti-inflammatory priming of HSCs. Here, we review the current understanding of and progression in research on the mechanistic interrelationships among lifestyle, HSC homeostasis, and cardiovascular health. Given that adhering to a healthy lifestyle has become a mainstream primary preventative approach to lowering the cardiovascular burden, unmasking the causal links between lifestyle and cardiovascular health from the perspective of hematopoiesis would open new opportunities to prevent and treat CVD in the present age.
摘要：
尽管现代医疗取得了突破，心血管疾病（CVD）的发病率在全球范围内更为普遍。越来越多的流行病学证据表明，由现代生活方式引起的新出现的心血管危险因素，包括心理社会压力,睡眠问题,不健康的饮食习惯,身体不活动/久坐行为，酒精消费,和吸烟，对这一全球流行病做出了重大贡献，虽然它的支撑机制是神秘的。血液和免疫系统最近被证明在将生活方式与心血管健康联系起来中起着综合作用。特别是,造血干细胞（HSC）稳态的改变，通常以增殖为特征，扩展,动员,巨核细胞/髓样偏倚分化，和/或HSC的促炎启动，已被证明与持续的促炎性骨髓白细胞和血小板过量生产有关，心血管炎症和血栓形成的细胞激动剂，分别。此外，某些生活方式因素，比如健康的饮食习惯和体育锻炼，已被证明通过促进静止发挥心血管保护作用，骨髓潴留,均衡分化，和/或HSC的抗炎引发。这里,我们回顾了目前对生活方式之间机制相互关系的理解和研究进展，HSC稳态，和心血管健康。鉴于坚持健康的生活方式已成为降低心血管负担的主流主要预防方法，从造血的角度揭示生活方式与心血管健康之间的因果关系,将为预防和治疗当代心血管疾病开辟新的机遇.
