PDF(Pubmed)
Abstract：
This review explores the likely clinical impact of Pregnane X Receptor (PXR) activation by vitamin K on human health. PXR, initially recognized as a master regulator of xenobiotic metabolism in liver, emerges as a key regulator influencing intestinal homeostasis, inflammation, oxidative stress, and autophagy. The activation of PXR by vitamin K highlights its role as a potent endogenous and local agonist with diverse clinical implications. Recent research suggests that the vitamin K-mediated activation of PXR highlights this vitamin\'s potential in addressing pathophysiological conditions by promoting hepatic detoxification, fortifying gut barrier integrity, and controlling pro-inflammatory and apoptotic pathways. PXR activation by vitamin K provides an intricate association with cancer cell survival, particularly in colorectal and liver cancers, to provide new insights into potential novel therapeutic strategies. Understanding the clinical implications of PXR activation by vitamin K bridges molecular mechanisms with health outcomes, further offering personalized therapeutic approaches for complex diseases.
摘要：
这篇综述探讨了维生素K激活孕烷X受体（PXR）对人体健康的可能临床影响。PXR,最初被认为是肝脏异种生物代谢的主要调节因子，作为影响肠道稳态的关键调节剂，炎症,氧化应激，和自噬。维生素K对PXR的激活强调了其作为具有不同临床意义的有效内源性和局部激动剂的作用。最近的研究表明，维生素K介导的激活PXR突出了这种维生素的潜力，在解决病理生理条件通过促进肝脏解毒，强化肠道屏障完整性，控制促炎和凋亡途径。维生素K激活PXR提供了与癌细胞存活的复杂关联，特别是在结直肠癌和肝癌中，为潜在的新治疗策略提供新的见解。了解维生素K激活PXR的临床意义与健康结果的分子机制，进一步为复杂疾病提供个性化治疗方法。
