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Abstract：
BACKGROUND: The compression of the median nerve within the carpal tunnel is the cause of carpal tunnel syndrome (CTS). Surgical decompression is successful in improving sleep and quality of life, but the effect of tissue adhesives as a material for wound closure has not been investigated. The objective of the study was to evaluate sleep disorders and health-related life quality by comparing two methods for wound closure after carpal surgery in participants who were randomized to receive tissue adhesives or transcutaneous sutures.
METHODS: The subjects, aged 61.56 ± 12.03 years, were randomized to receive either tissue adhesives (n = 50) or suture-based wound closure (n = 50) using the Glubran Tiss 2® skin adhesive after subcutaneous running sutures. The outcomes were assessed during the 12-month postoperative follow-up. The Pittsburgh Sleep Quality Index (PQSI) and Insomnia Severity Scale (ISI) were used for the sleep disturbance assessment, and for the health-related quality of life assessment, the total SF-36 (36-Item Short Form Survey) was used.
RESULTS: The PQSI, ISI, and SF-36 were not statistically different between groups during the follow-up, except in the ISI score two weeks after surgery (9.40 ± 1.18 in the tissue adhesive group vs. 9.96 ± 1.09 in the suture-based group, p = 0.008). The PQSI, ISI, and SF-36 scores for all the subjects and groups were persistently improved at all the follow-up intervals after surgery. The total SF-36 score increased 12 months after surgery (49.84 ± 5.85 vs. 82.46 ± 5.68, p < 0.001).
CONCLUSIONS: Cyanoacrylate-based adhesion material can be used for wound closure after open CTS decompression as a standard transcutaneous suture, and both techniques equally lead to improved sleep and life quality. The possible advantages of tissue adhesives include a faster reduction in the ISI.
METHODS: The subjects, aged 61.56 ± 12.03 years, were randomized to receive either tissue adhesives (n = 50) or suture-based wound closure (n = 50) using the Glubran Tiss 2® skin adhesive after subcutaneous running sutures. The outcomes were assessed during the 12-month postoperative follow-up. The Pittsburgh Sleep Quality Index (PQSI) and Insomnia Severity Scale (ISI) were used for the sleep disturbance assessment, and for the health-related quality of life assessment, the total SF-36 (36-Item Short Form Survey) was used.
RESULTS: The PQSI, ISI, and SF-36 were not statistically different between groups during the follow-up, except in the ISI score two weeks after surgery (9.40 ± 1.18 in the tissue adhesive group vs. 9.96 ± 1.09 in the suture-based group, p = 0.008). The PQSI, ISI, and SF-36 scores for all the subjects and groups were persistently improved at all the follow-up intervals after surgery. The total SF-36 score increased 12 months after surgery (49.84 ± 5.85 vs. 82.46 ± 5.68, p < 0.001).
CONCLUSIONS: Cyanoacrylate-based adhesion material can be used for wound closure after open CTS decompression as a standard transcutaneous suture, and both techniques equally lead to improved sleep and life quality. The possible advantages of tissue adhesives include a faster reduction in the ISI.
摘要：
背景：腕管正中神经受压是腕管综合征（CTS）的原因。手术减压在改善睡眠和生活质量方面是成功的,但是组织粘合剂作为伤口闭合材料的效果尚未得到研究。该研究的目的是通过比较随机接受组织粘合剂或经皮缝合的参与者的腕骨手术后两种伤口闭合方法来评估睡眠障碍和健康相关的生活质量。
方法：受试者，61.56±12.03岁，随机接受组织粘合剂（n=50）或基于缝合线的伤口闭合（n=50），使用GluranTiss2®皮肤粘合剂在皮下缝合后。在术后12个月随访期间评估结果。采用匹兹堡睡眠质量指数(PQSI)和失眠严重程度量表(ISI)进行睡眠障碍评估。以及与健康相关的生活质量评估，使用总SF-36(36项简表调查)。
结果：PQSI，ISI,和SF-36在随访期间组间没有统计学差异，除术后2周的ISI评分外（组织粘合剂组的9.40±1.18vs.缝合组9.96±1.09，p=0.008)。PQSI,ISI,在手术后的所有随访间隔内，所有受试者和组的SF-36评分均持续改善。术后12个月SF-36总评分增加(49.84±5.85vs.82.46±5.68，p<0.001）。
结论：基于氰基丙烯酸酯的粘连材料可作为标准经皮缝合在开放式CTS减压后用于伤口闭合，两种技术都能改善睡眠和生活质量。组织粘合剂的可能优点包括ISI的更快降低。
方法：受试者，61.56±12.03岁，随机接受组织粘合剂（n=50）或基于缝合线的伤口闭合（n=50），使用GluranTiss2®皮肤粘合剂在皮下缝合后。在术后12个月随访期间评估结果。采用匹兹堡睡眠质量指数(PQSI)和失眠严重程度量表(ISI)进行睡眠障碍评估。以及与健康相关的生活质量评估，使用总SF-36(36项简表调查)。
结果：PQSI，ISI,和SF-36在随访期间组间没有统计学差异，除术后2周的ISI评分外（组织粘合剂组的9.40±1.18vs.缝合组9.96±1.09，p=0.008)。PQSI,ISI,在手术后的所有随访间隔内，所有受试者和组的SF-36评分均持续改善。术后12个月SF-36总评分增加(49.84±5.85vs.82.46±5.68，p<0.001）。
结论：基于氰基丙烯酸酯的粘连材料可作为标准经皮缝合在开放式CTS减压后用于伤口闭合，两种技术都能改善睡眠和生活质量。组织粘合剂的可能优点包括ISI的更快降低。
