METHODS: The subjects, aged 61.56 ± 12.03 years, were randomized to receive either tissue adhesives (n = 50) or suture-based wound closure (n = 50) using the Glubran Tiss 2® skin adhesive after subcutaneous running sutures. The outcomes were assessed during the 12-month postoperative follow-up. The Pittsburgh Sleep Quality Index (PQSI) and Insomnia Severity Scale (ISI) were used for the sleep disturbance assessment, and for the health-related quality of life assessment, the total SF-36 (36-Item Short Form Survey) was used.
RESULTS: The PQSI, ISI, and SF-36 were not statistically different between groups during the follow-up, except in the ISI score two weeks after surgery (9.40 ± 1.18 in the tissue adhesive group vs. 9.96 ± 1.09 in the suture-based group, p = 0.008). The PQSI, ISI, and SF-36 scores for all the subjects and groups were persistently improved at all the follow-up intervals after surgery. The total SF-36 score increased 12 months after surgery (49.84 ± 5.85 vs. 82.46 ± 5.68, p < 0.001).
CONCLUSIONS: Cyanoacrylate-based adhesion material can be used for wound closure after open CTS decompression as a standard transcutaneous suture, and both techniques equally lead to improved sleep and life quality. The possible advantages of tissue adhesives include a faster reduction in the ISI.
方法:受试者,61.56±12.03岁,随机接受组织粘合剂(n=50)或基于缝合线的伤口闭合(n=50),使用GluranTiss2®皮肤粘合剂在皮下缝合后。在术后12个月随访期间评估结果。采用匹兹堡睡眠质量指数(PQSI)和失眠严重程度量表(ISI)进行睡眠障碍评估。以及与健康相关的生活质量评估,使用总SF-36(36项简表调查)。
结果:PQSI,ISI,和SF-36在随访期间组间没有统计学差异,除术后2周的ISI评分外(组织粘合剂组的9.40±1.18vs.缝合组9.96±1.09,p=0.008)。PQSI,ISI,在手术后的所有随访间隔内,所有受试者和组的SF-36评分均持续改善。术后12个月SF-36总评分增加(49.84±5.85vs.82.46±5.68,p<0.001)。
结论:基于氰基丙烯酸酯的粘连材料可作为标准经皮缝合在开放式CTS减压后用于伤口闭合,两种技术都能改善睡眠和生活质量。组织粘合剂的可能优点包括ISI的更快降低。