Abstract:
Objective: Negative pressure wound therapy (NPWT) and oxidized regenerated cellulose (ORC)/collagen/silver-ORC (OCSO) dressings have individually demonstrated effectiveness in supporting wound healing, but few studies have examined their combined use. This retrospective data analysis compared wound outcomes following outpatient NPWT with and without OCSO dressings. Approach: A search of deidentified records from the U.S. Wound Registry resulted in 485 cases of wounds managed with NPWT with OCSO dressings. A matched cohort of patients who received NPWT without any collagen dressing (n = 485) was created using propensity scoring. For patients in the NPWT + OCSO group, OCSO was applied topically on or after the day of NPWT initiation and stopped on or before the day of NPWT termination. Results: Wounds managed with NPWT + OCSO were significantly more likely to improve and/or heal compared with wounds that received NPWT alone (p = 0.00029). The relative wound area reduction was 40% for patients receiving NPWT + OCSO, compared with 9% for patients receiving only NPWT (p = 0.0099). The median time to achieve 75-100% granulation coverage with no measurable wound depth was shorter by 8 days with NPWT + OCSO in all wound types (p = 0.00034), and by 14 days in surgical wounds (p = 0.0010), than with NPWT alone. Innovation: This is the first study examining the clinical outcomes associated with the integration of NPWT and OCSO dressings compared with the use of NPWT alone. These data support the novel practice of applying NPWT concurrently with OCSO dressings. Conclusion: This retrospective comparative analysis using real-world data demonstrated improved healing outcomes with integrated use of NPWT with OCSO dressings versus NPWT alone.
摘要:
目的:负压伤口治疗(NPWT)和氧化再生纤维素(ORC)/胶原蛋白/银-ORC(OCSO)敷料在支持伤口愈合方面分别证明了有效性,但是很少有研究检查它们的结合使用。这项回顾性数据分析比较了使用和不使用OCSO敷料的门诊NPWT后的伤口结局。
方法:从美国伤口登记处检索去识别的记录,发现有485例伤口采用OCSO敷料进行NPWT处理。使用倾向评分创建了一个匹配的接受NPWT而没有任何胶原蛋白敷料的患者队列(n=485)。对于NPWT+OCSO组的患者,在NPWT启动当天或之后局部应用OCSO,并在NPWT终止当天或之前停止。
结果:与单独接受NPWT的伤口相比,使用NPWT+OCSO治疗的伤口更有可能改善和/或愈合(p=0.00029)。接受NPWT+OCSO的患者的相对伤口面积减少为40%,相比之下,仅接受NPWT的患者为9%(p=0.0099)。在所有伤口类型中,使用NPWT+OCSO,在没有可测量的伤口深度的情况下,达到75-100%肉芽覆盖率的中位时间缩短了8天(p=0.00034),手术伤口14天(p=0.0010),而不是单独使用NPWT。
方法:这是第一项研究,与单独使用NPWT相比,与NPWT和OCSO敷料的整合相关的临床结果。这些数据支持与OCSO敷料同时应用NPWT的新颖实践。
结论:这项使用真实世界数据的回顾性比较分析显示,与单独使用NPWT相比,NPWT与OCSO敷料的综合使用改善了愈合效果。