PDF(Pubmed)
Abstract：
UNASSIGNED: Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain regions. Different brain connection abnormalities were found to be correlated with various clinical manifestations, but whether a common deficit in functional connectivity (FC) in relation to both clinical symptoms and cognitive impairments could present in first-episode patients who have never received any medication remains elusive.
UNASSIGNED: To find a core deficit in the brain connectome that is related to both psychopathological and cognitive manifestations.
UNASSIGNED: A total of 75 patients with first-episode schizophrenia and 51 healthy control participants underwent scanning of the brain and clinical ratings of behaviors. A principal component analysis was performed on the clinical ratings of symptom and cognition. Partial correlation analyses were conducted between the main psychopathological components and resting-state FC that were found abnormal in schizophrenia patients.
UNASSIGNED: Using the principal component analysis, the first principal component (PC1) explained 37% of the total variance of seven clinical features. The ratings of GAF and BACS contributed negatively to PC1, while those of PANSS, HAMD, and HAMA contributed positively. The FCs positively correlated with PC1 mainly included connections related to the insula, precuneus gyrus, and some frontal brain regions. FCs negatively correlated with PC1 mainly included connections between the left middle cingulate cortex and superior and middle occipital regions.
UNASSIGNED: In conclusion, we found a linked pattern of FC associated with both psychopathological and cognitive manifestations in drug-naïve first-episode schizophrenia characterized as the dysconnection related to the frontal and visual cortex, which may represent a core deficit of brain FC in patients with schizophrenia.
UNASSIGNED: To find a core deficit in the brain connectome that is related to both psychopathological and cognitive manifestations.
UNASSIGNED: A total of 75 patients with first-episode schizophrenia and 51 healthy control participants underwent scanning of the brain and clinical ratings of behaviors. A principal component analysis was performed on the clinical ratings of symptom and cognition. Partial correlation analyses were conducted between the main psychopathological components and resting-state FC that were found abnormal in schizophrenia patients.
UNASSIGNED: Using the principal component analysis, the first principal component (PC1) explained 37% of the total variance of seven clinical features. The ratings of GAF and BACS contributed negatively to PC1, while those of PANSS, HAMD, and HAMA contributed positively. The FCs positively correlated with PC1 mainly included connections related to the insula, precuneus gyrus, and some frontal brain regions. FCs negatively correlated with PC1 mainly included connections between the left middle cingulate cortex and superior and middle occipital regions.
UNASSIGNED: In conclusion, we found a linked pattern of FC associated with both psychopathological and cognitive manifestations in drug-naïve first-episode schizophrenia characterized as the dysconnection related to the frontal and visual cortex, which may represent a core deficit of brain FC in patients with schizophrenia.
摘要：
精神分裂症被认为是一种以不同脑区之间的功能整合异常为特征的连接障碍。发现不同的脑连接异常与各种临床表现相关，但从未接受过任何药物治疗的首发患者是否会出现与临床症状和认知障碍相关的功能连接(FC)共同缺陷,目前尚不清楚.
■在大脑连接体中发现与精神病理学和认知表现有关的核心缺陷。
■共有75名首发精神分裂症患者和51名健康对照参与者接受了脑部扫描和行为临床评分。对症状和认知的临床评分进行主成分分析。在精神分裂症患者中发现的主要精神病理成分与静息状态FC之间进行了偏相关分析。
■使用主成分分析，第一主成分(PC1)解释了7个临床特征总方差的37%.GAF和BACS的评级对PC1有负面影响，而PANSS的评级，HAMD,HAMA做出了积极贡献。与PC1呈正相关的FC主要包括与脑岛相关的连接，前回,和一些额叶大脑区域。与PC1呈负相关的FCs主要包括左中扣带皮质与上枕中区域之间的连接。
■总而言之，我们发现FC的关联模式与首次发作精神分裂症的精神病理学和认知表现相关，其特征是与额叶和视觉皮层有关的连接障碍。这可能代表精神分裂症患者脑FC的核心缺陷。
■在大脑连接体中发现与精神病理学和认知表现有关的核心缺陷。
■共有75名首发精神分裂症患者和51名健康对照参与者接受了脑部扫描和行为临床评分。对症状和认知的临床评分进行主成分分析。在精神分裂症患者中发现的主要精神病理成分与静息状态FC之间进行了偏相关分析。
■使用主成分分析，第一主成分(PC1)解释了7个临床特征总方差的37%.GAF和BACS的评级对PC1有负面影响，而PANSS的评级，HAMD,HAMA做出了积极贡献。与PC1呈正相关的FC主要包括与脑岛相关的连接，前回,和一些额叶大脑区域。与PC1呈负相关的FCs主要包括左中扣带皮质与上枕中区域之间的连接。
■总而言之，我们发现FC的关联模式与首次发作精神分裂症的精神病理学和认知表现相关，其特征是与额叶和视觉皮层有关的连接障碍。这可能代表精神分裂症患者脑FC的核心缺陷。
