PDF(Pubmed)
Abstract：
The link between cognitive function and emotion regulation may be helpful in better understanding the onset, maintenance, and treatment for depression. However, it remains unclear whether there are neural correlates between emotion dysregulation and cognitive deficits in depression. To address this question, we first review the neural representations of emotion dysregulation and cognitive deficits in depression (including deficits in cognitive control and cognitive biases). Based on the comparisons of neural representations of emotion dysregulation versus cognitive deficits, we propose an accessible and reasonable link between emotion dysregulation, cognitive control, and cognitive biases in depression. Specifically, cognitive control serves the whole process of emotion regulation, whereas cognitive biases are engaged in emotion regulation processes at different stages. Moreover, the abnormal implementation of different emotion regulation strategies in depression is consistently affected by cognitive control, which is involved in the dorsolateral, the dorsomedial prefrontal cortex, and the anterior cingulate cortex. Besides, the relationship between different emotion regulation strategies and cognitive biases in depression may be distinct: the orbitofrontal cortex contributes to the association between ineffective reappraisal and negative interpretation bias, while the subgenual prefrontal cortex and the posterior cingulate cortex underline the tendency of depressed individuals to ruminate and overly engage in self-referential bias. This review sheds light on the relationship between cognitive deficits and emotion dysregulation in depression and identifies directions in need of future attention.
摘要：
认知功能和情绪调节之间的联系可能有助于更好地理解发病，维护,和治疗抑郁症。然而,目前尚不清楚抑郁患者的情绪失调和认知缺陷之间是否存在神经相关性.为了解决这个问题，我们首先回顾了抑郁症中情绪失调和认知缺陷（包括认知控制缺陷和认知偏差）的神经表现。基于情绪失调与认知缺陷的神经表征的比较，我们提出了情绪失调之间的可访问和合理的联系，认知控制，和抑郁症的认知偏见。具体来说,认知控制服务于情绪调节的全过程,而认知偏差在不同阶段参与情绪调节过程。此外，不同情绪调节策略在抑郁症中的异常执行始终受到认知控制的影响，涉及背外侧，背侧前额叶皮层，和前扣带皮质。此外,不同的情绪调节策略与抑郁症认知偏差之间的关系可能是不同的:眶额叶皮层有助于无效的重新评价和负面解释偏差之间的关联，而后代前额叶皮层和后扣带皮层强调了抑郁个体反思性和过度参与自我参照偏见的趋势。这篇综述阐明了抑郁症中认知缺陷与情绪失调之间的关系，并确定了未来需要关注的方向。
