Abstract：
Addressing poor solubility and permeability issues associated with synthetic drugs and naturally occurring active compounds is crucial for improving bioavailability. This review explores the potential of phospholipid complex formulation technology to overcome these challenges. Phospholipids, as endogenous molecules, offer a viable solution, with drugs complexed with phospholipids demonstrating a similar absorption mechanism. The non-toxic and biodegradable nature of the phospholipid complex positions it as an ideal candidate for drug delivery. This article provides a comprehensive exploration of the mechanisms underlying phospholipid complexes. Special emphasis is placed on the solvent evaporation method, with meticulous scrutiny of formulation aspects such as the phospholipid ratio to the drug and solvent. Characterization techniques are employed to understand structural and functional attributes. Highlighting the adaptability of the phospholipid complex, the review discusses the loading of various nanoformulations and emulsion systems. These strategies aim to enhance drug delivery and efficacy in various malignancies, including breast, liver, lung, cervical, and pancreatic cancers. The broader application of the drug phospholipid complex is showcased, emphasizing its adaptability in diverse oncological settings. The review not only explores the mechanisms and formulation aspects of phospholipid complexes but also provides an overview of key clinical studies and patents. These insights contribute to the intellectual and translational advancements in drug phospholipid complexes.
摘要：
解决与合成药物和天然存在的活性化合物相关的不良溶解性和渗透性问题对于提高生物利用度至关重要。这篇综述探讨了磷脂复合物制剂技术克服这些挑战的潜力。磷脂，作为内源性分子，提供一个可行的解决方案，与磷脂复合的药物表现出相似的吸收机制。磷脂复合物的无毒和可生物降解的性质将其定位为药物递送的理想候选物。本文提供了对磷脂复合物潜在机制的全面探索。特别强调溶剂蒸发法，仔细审查配方方面，如磷脂与药物和溶剂的比例。采用表征技术来理解结构和功能属性。突出磷脂复合物的适应性，该综述讨论了各种纳米制剂和乳液系统的负载。这些策略旨在增强各种恶性肿瘤的药物递送和疗效。包括乳房,肝脏,肺，子宫颈,和胰腺癌。显示了药物磷脂复合物的更广泛的应用，强调其在不同肿瘤环境中的适应性。该综述不仅探讨了磷脂复合物的机制和配方方面，而且还概述了关键的临床研究和专利。这些见解有助于药物磷脂复合物的智力和翻译进步。
