PDF(Pubmed)
Abstract：
Vitamin B12 is required for the formation of haematopoietic cells and the synthesis of myelin. Deficiency typically presents with fatigue and megaloblastic anaemia. Prolonged deficiency can cause neurological symptoms such as paresthesia, which can progress to subacute combined degeneration of the spinal cord. We describe an unusual presentation of B12 deficiency in a young man who was initially diagnosed and treated for cervical radiculopathy. This case highlights the challenges of diagnosing B12 deficiency in patients with neurologic but without haematologic, abnormalities. While the current incidence of B12 deficiency in developed countries is low, cases are likely to rise with the increased adoption of veganism. Clinicians should be aware of the variable presentations of B12 deficiency because delayed diagnosis and treatment increases morbidity and can cause irreversible neurological deficits.
摘要：
维生素B12是造血细胞形成和髓鞘合成所必需的。缺乏通常表现为疲劳和巨幼细胞性贫血。长期缺乏会导致神经症状，如感觉异常，可进展为脊髓亚急性联合变性。我们描述了最初被诊断并接受颈神经根病治疗的年轻人的B12缺乏症的不寻常表现。这个病例突出了在有神经系统但没有血液学的患者中诊断B12缺乏症的挑战，异常。虽然发达国家目前的B12缺乏症发病率很低，随着素食主义的增加，病例可能会增加。临床医生应该意识到B12缺乏症的各种表现，因为延迟诊断和治疗会增加发病率，并可能导致不可逆的神经功能缺损。
